دورية أكاديمية
أعرض في EDS

Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns

التفاصيل البيبلوغرافية
العنوان: Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns
المؤلفون: Olivia M. de Goede, Pascal M. Lavoie, Wendy P. Robinson
المصدر: Clinical Epigenetics, Vol 9, Iss 1, Pp 1-13 (2017)
بيانات النشر: BMC, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Genetics
مصطلحات موضوعية: DNA methylation, Cord blood, Preterm birth, Illumina 450K array, Epigenetics, Nucleated red blood cells, Medicine, Genetics, QH426-470
الوصف: Abstract Background Premature infants are highly vulnerable to infection. This is partly attributable to the preterm immune system, which differs from that of the term neonate in cell composition and function. Multiple studies have found differential DNA methylation (DNAm) between preterm and term infants’ cord blood; however, interpretation of these studies is limited by the confounding factor of blood cell composition. This study evaluates the epigenetic impact of preterm birth in isolated hematopoietic cell populations, reducing the concern of cell composition differences. Methods Genome-wide DNAm was measured using the Illumina 450K array in T cells, monocytes, granulocytes, and nucleated red blood cells (nRBCs) isolated from cord blood of 5 term and 5 preterm ( 0.10) discovered between preterm and term infants compared to the
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1868-7075
1868-7083
العلاقة: http://link.springer.com/article/10.1186/s13148-017-0339-1Test; https://doaj.org/toc/1868-7075Test; https://doaj.org/toc/1868-7083Test
DOI: 10.1186/s13148-017-0339-1
الوصول الحر: https://doaj.org/article/eb70d81720194e98b71257f55798f755Test
رقم الانضمام: edsdoj.b70d81720194e98b71257f55798f755
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:18687075
18687083
DOI:10.1186/s13148-017-0339-1