دورية أكاديمية
Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation
| العنوان: | Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation |
|---|---|
| المؤلفون: | Chaekyun Kim |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 20, p 15342 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | bone, osteoclast, macrophage colony-stimulating factor (M-CSF), receptor activator of nuclear factor kappa-B ligand (RANKL), mitogen-activated protein kinases (MAPKs), extracellular signal-regulated kinases (ERKs), Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Bone homeostasis is regulated by the balanced actions of osteoblasts that form the bone and osteoclasts (OCs) that resorb the bone. Bone-resorbing OCs are differentiated from hematopoietic monocyte/macrophage lineage cells, whereas osteoblasts are derived from mesenchymal progenitors. OC differentiation is induced by two key cytokines, macrophage colony-stimulating factor (M-CSF), a factor essential for the proliferation and survival of the OCs, and receptor activator of nuclear factor kappa-B ligand (RANKL), a factor for responsible for the differentiation of the OCs. Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), p38, and c-Jun N-terminal kinases, play an essential role in regulating the proliferation, differentiation, and function of OCs. ERKs have been known to play a critical role in the differentiation and activation of OCs. In most cases, ERKs positively regulate OC differentiation and function. However, several reports present conflicting conclusions. Interestingly, the inhibition of OC differentiation by ERK1/2 is observed only in OCs differentiated from RAW 264.7 cells. Therefore, in this review, we summarize the current understanding of the conflicting actions of ERK1/2 in OC differentiation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/24/20/15342Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms242015342 |
| الوصول الحر: | https://doaj.org/article/b6753d0bf94145ba899268c9d0d961bdTest |
| رقم الانضمام: | edsdoj.b6753d0bf94145ba899268c9d0d961bd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
|---|---|
| DOI: | 10.3390/ijms242015342 |