دورية أكاديمية
Gamma-aminobutyric acid for delaying type 1 diabetes mellitus: an update
| العنوان: | Gamma-aminobutyric acid for delaying type 1 diabetes mellitus: an update |
|---|---|
| المؤلفون: | Jane Carissa Sutedja, Bryan Gervais de Liyis, Made Ratna Saraswati |
| المصدر: | Annals of Pediatric Endocrinology & Metabolism, Vol 29, Iss 3, Pp 142-151 (2024) |
| بيانات النشر: | Korean Society of Pediatric Endocrinology, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Pediatrics |
| مصطلحات موضوعية: | child, type 1 diabetes mellitus, gamma-aminobutyric acid, Pediatrics, RJ1-570 |
| الوصف: | The current gold-standard management of hyperglycemia in individuals with type 1 diabetes mellitus (T1DM) is insulin therapy. However, this therapy is associated with a high incidence of complications, and delaying the onset of this disease produces a substantially positive impact on quality of life for individuals with a predisposition to T1DM, especially children. This review aimed to assess the use of gamma-aminobutyric acid (GABA) to delay the onset of T1DM in children. GABA produces protective and proliferative effects in 2 ways, β cell and immune cell modulation. Various in vitro and in vivo studies have shown that GABA induces proliferation of β cells, increases insulin levels, inhibits β-cell apoptosis, and suppresses T helper 1 cell activity against islet antigens. Oral GABA is safe as no serious adverse effects were reported in any of the studies included in this review. These findings demonstrate promising results for the use of GABA treatment to delay T1DM, specifically in genetically predisposed children, through immunoregulatory effects and the ability to induce β-cell proliferation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2287-1012 2287-1292 |
| العلاقة: | http://e-apem.org/upload/pdf/apem-2346184-092.pdfTest; https://doaj.org/toc/2287-1012Test; https://doaj.org/toc/2287-1292Test |
| DOI: | 10.6065/apem.2346184.092 |
| الوصول الحر: | https://doaj.org/article/b36c2cd2309342aaa2513b7a33e129f8Test |
| رقم الانضمام: | edsdoj.b36c2cd2309342aaa2513b7a33e129f8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22871012 22871292 |
|---|---|
| DOI: | 10.6065/apem.2346184.092 |