دورية أكاديمية
Clinical Outcomes of Topical 0.1% Ciclosporin Cationic Emulsion Used on Label in Children with Vernal Keratoconjunctivitis
| العنوان: | Clinical Outcomes of Topical 0.1% Ciclosporin Cationic Emulsion Used on Label in Children with Vernal Keratoconjunctivitis |
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| المؤلفون: | Giuseppe Giannaccare, Costanza Rossi, Massimiliano Borselli, Chiara Bonzano, Giovanna Carnovale Scalzo, Massimo Nicolò, Vincenzo Scorcia, Carlo Enrico Traverso, Aldo Vagge |
| المصدر: | Ophthalmology and Therapy, Vol 12, Iss 3, Pp 1787-1793 (2023) |
| بيانات النشر: | Adis, Springer Healthcare, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Ophthalmology |
| مصطلحات موضوعية: | Allergic keratoconjunctivitis, Cationic emulsion, Ciclosporin, Verkazia, Vernal keratoconjunctivitis, Ophthalmology, RE1-994 |
| الوصف: | Abstract Introduction The purpose of this short article is to report the clinical outcomes of topical 0.1% ciclosporin cationic emulsion (CsA-CE) used on label in children with vernal keratoconjunctivitis (VKC). Methods In this prospective, non-comparative, observational study children affected by active severe VKC were treated for at least 12 months with topical 0.1% CsA-CE. The drug was instilled in both eyes 4 times daily. Data collected from medical charts for the baseline visit (T0) and 1-year follow-up visit (T1) included symptomatic score (0–15), clinical score (0–15), side effects, rescue therapy (need and total number of courses with 0.1% dexamethasone 4 times daily for 5 days), ocular complications and tolerability (visual analog scale [0–100]). Results Data from 25 children (20 boys, 5 girls; mean [± standard deviation] age 8.40 ± 2.54 years) were included in the study. Of the 25 patients, 23 (92%) used 0.1% CsA-CE eye drops as per label recommendations, including four patients who had prematurely stopped using topical galenic CsA due to side effects. Symptomatic and clinical scores decreased significantly after treatment, with the mean symptomatic score decreasing from 9.76 ± 1.27 at T0 to 3.80 ± 1.08 at T1, and the mean clinical score decreasing from 9.20 ± 1.32 at T0 to 3.44 ± 1.00 at T1; both P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2193-8245 2193-6528 |
| العلاقة: | https://doaj.org/toc/2193-8245Test; https://doaj.org/toc/2193-6528Test |
| DOI: | 10.1007/s40123-023-00707-y |
| الوصول الحر: | https://doaj.org/article/b2004db4550f48939652a18e81124350Test |
| رقم الانضمام: | edsdoj.b2004db4550f48939652a18e81124350 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21938245 21936528 |
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| DOI: | 10.1007/s40123-023-00707-y |