دورية أكاديمية
Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation.
| العنوان: | Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation. |
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| المؤلفون: | Kotaro Suzuki, Samantha H Murphy, Yifeng Xia, Masaya Yokota, Daiki Nakagomi, Fei Liu, Inder M Verma, Hiroshi Nakajima |
| المصدر: | PLoS ONE, Vol 6, Iss 9, p e25412 (2011) |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Mast cells are known to play a pivotal role in allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis by releasing granules containing histamine, LTC4, and other preformed chemical mediators. Previous reports have demonstrated that IKK2 (also called IKKβ), a central intracellular component of NF-κB activation pathways, plays a critical role in IgE-mediated degranulation of mast cells and anaphylaxis in mice. In this study, we show that protein levels of tumor suppressor p53 are up-regulated upon IgE-mediated activation in mast cells and lack of p53 results in enhanced responses in both early and late phase anaphylaxis. p53 inhibits not only the catalytic activity of IKK2 presumably through the modulation of glycosylation but also p65 (RelA)-mediated transactivation. Our findings are the first to demonstrate that p53 functions as a negative regulator in mast cells. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | http://europepmc.org/articles/PMC3179515?pdf=renderTest; https://doaj.org/toc/1932-6203Test |
| DOI: | 10.1371/journal.pone.0025412 |
| الوصول الحر: | https://doaj.org/article/b18c6319f2204515b8636cd3c70d47feTest |
| رقم الانضمام: | edsdoj.b18c6319f2204515b8636cd3c70d47fe |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0025412 |