دورية أكاديمية
Relationship between the Responsiveness of Amyloid β Protein to Platelet Activation by TRAP Stimulation and Brain Atrophy in Patients with Diabetes Mellitus
| العنوان: | Relationship between the Responsiveness of Amyloid β Protein to Platelet Activation by TRAP Stimulation and Brain Atrophy in Patients with Diabetes Mellitus |
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| المؤلفون: | Takamitsu Hori, Daisuke Mizutani, Takashi Onuma, Yu Okada, Kumi Kojima, Tomoaki Doi, Yukiko Enomoto, Hiroki Iida, Shinji Ogura, Takashi Sakurai, Toru Iwama, Osamu Kozawa, Haruhiko Tokuda |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 22, p 14100 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | Amyloid β protein, platelet, thrombin receptor-activating protein, platelet-derived growth factor, diabetes mellitus, brain atrophy, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Type 2 DM is a risk factor for dementia, including Alzheimer’s disease (AD), and is associated with brain atrophy. Amyloid β protein (Aβ) deposition in the brain parenchyma is implicated in the neurodegeneration that occurs in AD. Platelets, known as abundant storage of Aβ, are recognized to play important roles in the onset and progression of AD. We recently showed that Aβ negatively regulates platelet activation induced by thrombin receptor-activating protein (TRAP) in healthy people. In the present study, we investigated the effects of Aβ on the TRAP-stimulated platelet activation in DM patients, and the relationship between the individual responsiveness to Aβ and quantitative findings of MRI, the volume of white matter hyperintensity (WMH)/intracranial volume (IC) and the volume of parenchyma (PAR)/IC. In some DM patients, Aβ reduced platelet aggregation induced by TRAP, while in others it was unchanged or rather enhanced. The TRAP-induced levels of phosphorylated-Akt and phosphorylated-HSP27, the levels of PDGF-AB and the released phosphorylated-HSP27 correlated with the degree of platelet aggregability. The individual levels of not WMH/IC but PAR/IC was correlated with those of TRAP-stimulated PDGF-AB release. Collectively, our results suggest that the reactivity of TRAP-stimulated platelet activation to Aβ differs in DM patients from healthy people. The anti-suppressive feature of platelet activation to Aβ might be protective for brain atrophy in DM patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 23221410 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/23/22/14100Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms232214100 |
| الوصول الحر: | https://doaj.org/article/b062839398a24999a858e63e67f7c8daTest |
| رقم الانضمام: | edsdoj.b062839398a24999a858e63e67f7c8da |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23221410 14220067 16616596 |
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| DOI: | 10.3390/ijms232214100 |