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Capparis spinosa improves non-alcoholic steatohepatitis through down-regulating SREBP-1c and a PPARα-independent pathway in high-fat diet-fed rats

التفاصيل البيبلوغرافية
العنوان: Capparis spinosa improves non-alcoholic steatohepatitis through down-regulating SREBP-1c and a PPARα-independent pathway in high-fat diet-fed rats
المؤلفون: Rasoul Akbari, Hamid Yaghooti, Mohammad Taha Jalali, Laya Sadat Khorsandi, Narges Mohammadtaghvaei
المصدر: BMC Research Notes, Vol 15, Iss 1, Pp 1-8 (2022)
بيانات النشر: BMC, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
LCC:Biology (General)
LCC:Science (General)
مصطلحات موضوعية: Capparis spinosa, NASH, SREBP-1c, ACC, PPARα, CPT1, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
الوصف: Abstract Objective Non-alcoholic steatohepatitis (NASH) has become a global medical problem. Currently, there is no approved pharmacologic treatment for this condition. Previous studies have suggested that in the pathogenesis of this disease, regulatory pathways associated with de novo lipogenesis and β-oxidation pathways genes are misregulated. Capparis spinosa (CS) belongs to the family of Capparidaceae and is a traditional plant used to treat various diseases, particularly dyslipidemia. The compounds and extracts of this plant in In vivo and in vitro studies resulted in a reduction in lipid profiles and glucose. However, the mechanism of these effects remains unknown. This study aimed to evaluate the effects of (CS) fruit extract on NASH compared to fenofibrate and explored the related molecular mechanism. Results In the rats (n = 40) model of NASH, biochemical and histopathological examinations showed that liver steatosis, inflammation, and hepatic fibrosis were markedly attenuated in response to CS and fenofibrate interventions. At the molecular level, CS treatment down-regulated sterol regulatory element-binding protein-1c (SREBP-1c) (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1756-0500
العلاقة: https://doaj.org/toc/1756-0500Test
DOI: 10.1186/s13104-022-06205-x
الوصول الحر: https://doaj.org/article/a9feae1a26704f0ba5a4e2c4fa1bf36cTest
رقم الانضمام: edsdoj.9feae1a26704f0ba5a4e2c4fa1bf36c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17560500
DOI:10.1186/s13104-022-06205-x