دورية أكاديمية
Cord Blood Metabolite Profiles and Their Association with Autistic Traits in Childhood
| العنوان: | Cord Blood Metabolite Profiles and Their Association with Autistic Traits in Childhood |
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| المؤلفون: | Christin S. Kaupper, Sophia M. Blaauwendraad, Charlotte A. M. Cecil, Rosa H. Mulder, Romy Gaillard, Romy Goncalves, Ingo Borggraefe, Berthold Koletzko, Vincent W. V. Jaddoe |
| المصدر: | Metabolites, Vol 13, Iss 11, p 1140 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Microbiology |
| مصطلحات موضوعية: | metabolomics, cord blood metabolomics, ASD, autism spectrum disorder, sphingomyelines, non-esterified fatty acids, Microbiology, QR1-502 |
| الوصف: | Autism Spectrum Disorder (ASD) is a diverse neurodevelopmental condition. Gene–environmental interactions in early stages of life might alter metabolic pathways, possibly contributing to ASD pathophysiology. Metabolomics may serve as a tool to identify underlying metabolic mechanisms contributing to ASD phenotype and could help to unravel its complex etiology. In a population-based, prospective cohort study among 783 mother–child pairs, cord blood serum concentrations of amino acids, non-esterified fatty acids, phospholipids, and carnitines were obtained using liquid chromatography coupled with tandem mass spectrometry. Autistic traits were measured at the children’s ages of 6 (n = 716) and 13 (n = 648) years using the parent-reported Social Responsiveness Scale. Lower cord blood concentrations of SM.C.39.2 and NEFA16:1/16:0 were associated with higher autistic traits among 6-year-old children, adjusted for sex and age at outcome. After more stringent adjustment for confounders, no significant associations of cord blood metabolites and autistic traits at ages 6 and 13 were detected. Differences in lipid metabolism (SM and NEFA) might be involved in ASD-related pathways and are worth further investigation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13111140 2218-1989 |
| العلاقة: | https://www.mdpi.com/2218-1989/13/11/1140Test; https://doaj.org/toc/2218-1989Test |
| DOI: | 10.3390/metabo13111140 |
| الوصول الحر: | https://doaj.org/article/9f4e2618742949f4995bc199b649796eTest |
| رقم الانضمام: | edsdoj.9f4e2618742949f4995bc199b649796e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13111140 22181989 |
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| DOI: | 10.3390/metabo13111140 |