دورية أكاديمية
Allogeneic Stem Cell Transplantation with a Novel Reduced Intensity Conditioning Regimen for the Treatment of Patients with Primary Cutaneous T-cell Lymphomas
| العنوان: | Allogeneic Stem Cell Transplantation with a Novel Reduced Intensity Conditioning Regimen for the Treatment of Patients with Primary Cutaneous T-cell Lymphomas |
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| المؤلفون: | Maria Stamouli, Konstantinos Gkirkas, Aggeliki Karagiannidi, Theodoros Iliakis, Spiros Chondropoulos, Thomas Thomopoulos, Vassiliki Nikolaou, Vassiliki Pappa, Evangelia Papadavid, Panagiotis Tsirigotis |
| المصدر: | Clinical Hematology International, Vol 3, Iss 2 (2021) |
| بيانات النشر: | SAABRON PRESS, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | Mycosis fungoides, sezary syndrome, cutaneous t-cell lymphomas, donor lymphocyte infusion, allogeneic stem cell transplantation, graft-versus-host disease, Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | The prognosis of patients with mycosis fungoides (MF) and Sezary Syndrome (SS) varies greatly, from near normal life expectancy in patients with early stage, to a median survival of less than 2 years for those diagnosed with advanced stage disease. Initial response to treatment is almost always followed by relapse and, finally, most of patients enter a phase of advanced multi-drug resistant disease with a short life expectancy after multiple lines of treatment. Allogeneic stem cell transplantation (allo-SCT) is usually limited to patients with advanced disease resistant to multiple treatments. Retrospective registry-based studies have shown increased Non-relapse Mortality (NRM) rates in patients with poor performance status, as well as in patients treated with myeloablative conditioning regimens. Another major limitation of allo-SCT is the increased relapse rate which occurs in nearly 50% of the cases, and is probably due to the fact that only heavily pretreated patients with advanced disease are referred for allo-SCT. Due to the paucity of data, the ideal conditioning regimen which will provide the maximum therapeutic benefit without the cost of increased NRM is not currently known. In this article we present our experience with a novel regimen in the treatment of patients with advanced MF/SS. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 12595772 2590-0048 |
| العلاقة: | https://www.atlantis-press.com/article/125957728/viewTest; https://doaj.org/toc/2590-0048Test |
| DOI: | 10.2991/chi.k.210529.001 |
| الوصول الحر: | https://doaj.org/article/9db5653ae4eb416b8e87adb4ec2be131Test |
| رقم الانضمام: | edsdoj.9db5653ae4eb416b8e87adb4ec2be131 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12595772 25900048 |
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| DOI: | 10.2991/chi.k.210529.001 |