دورية أكاديمية
Role of the Nitrergic System of the Cuneiform Nucleus in Cardiovascular Responses in Urethane-Anesthetized Male Rats
| العنوان: | Role of the Nitrergic System of the Cuneiform Nucleus in Cardiovascular Responses in Urethane-Anesthetized Male Rats |
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| المؤلفون: | Esmaeil Farrokhi, Mohammad Naser Shafei, Abolfazl Khajavirad, Mahmoud Hosseini, Ali Reza Ebrahimzadeh Bideskan |
| المصدر: | Iranian Journal of Medical Sciences, Vol 42, Iss 5, Pp 473-480 (2017) |
| بيانات النشر: | Shiraz University of Medical Sciences, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Cuneiform nucleus, Nitroprusside, Nitric oxide, Blood pressure, NG-nitro-L-arginine methyl ester, Medicine (General), R5-920 |
| الوصف: | Background: The presence of nitric oxide (NO) in the cuneiform nucleus (CnF) has been previously shown. In this study, NG-nitro-L-arginine methyl ester (L-NAME) (an inhibitor of NO synthase), L-arginine (L-Arg) (a precursor of NO), and sodium nitroprusside (SNP) (a donor of NO) were microinjected into the CnF and cardiovascular responses were investigated. Methods: Seventy male rats were divided into 7 groups (n=10 each): 1) saline, 2 and 3) L-NAME (30 and 90 nmol), 4 and 5) L-Arg (20 and 60 nmol), and 6 and 7) SNP (9 and 27 nmol). After anesthesia, the femoral artery was cannulated and cardiovascular parameters were recorded using a PowerLab system. Time course changes in mean arterial pressure (ΔMAP) and heart rate (ΔHR) were calculated and compared with those in the control group (repeated measures ANOVA). Maximum ∆MAP and ∆HR were also compared with those in the control group (independent sample t test). Results: ∆MAP with both doses of L-NAME (30: P=0.026 and 90: P=0.007) and ∆HR with the higher dose (P=0.034) were significantly higher than those in the control group. Maximal ∆MAP with both doses (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0253-0716 1735-3688 |
| العلاقة: | http://ijms.sums.ac.ir/index.php/IJMS/article/view/3082Test; https://doaj.org/toc/0253-0716Test; https://doaj.org/toc/1735-3688Test |
| الوصول الحر: | https://doaj.org/article/9d37bd787f3b44c0a84567e304047ed2Test |
| رقم الانضمام: | edsdoj.9d37bd787f3b44c0a84567e304047ed2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 02530716 17353688 |
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