دورية أكاديمية
Assessment of quality of life in patients with craniopharyngioma and identification of risk factors for compromised overall wellness
| العنوان: | Assessment of quality of life in patients with craniopharyngioma and identification of risk factors for compromised overall wellness |
|---|---|
| المؤلفون: | Ben Lin, Shiyuan Xiang, Jiajun Chen, Yu Jing, Zhao Ye, Yichao Zhang, Xiaoyun Cao, Zhiwen Yin, Nidan Qiao, Xiang Zhou |
| المصدر: | Archives of Endocrinology and Metabolism, Vol 68 (2024) |
| بيانات النشر: | Brazilian Society of Endocrinology and Metabolism, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Craniopharyngioma, quality of life, depression, central diabetes insipidus, Medicine, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | ABSTRACT Objective: Quality of Life (QoL) has been a multifactorial concerning issue in oncology. We aimed to inspect the pre-operative QoL among patients with craniopharyngioma and to explore the potential correlations between parameters of QoL and clinical indices. Subjects and methods: We enrolled a total of 109 patients with craniopharyngioma. We utilized Short Form 36 (SF-36), Symptom Check List-90, Generalized Anxiety Disorder Questionnaire scale (GAD7), Patient Health Questionnaire Depression (PHQ9) and Pittsburgh Sleep Quality Index to prospectively evaluated their QoL. Parameters of QoL along with clinical indices were compared among sub-groups divided according to Puget classification. Correlation analyses and regression analyses were performed to detect influential determinants to self-reported wellness. Results: Patients presented impaired QoL compared with general population ( p < 0.001), as assessed by SF-36. Correlation analyses indicated the detrimental influence resulting from central diabetes insipidus (CDI). Multivariate linear regression unveiled the adverse effect of CDI on Mental Component Summary (coefficient = −13.869, p = 0.007), GAD7 total score (coefficient = 2.072, p = 0.049) as well as PHQ9 total score (coefficient = 3.721, p = 0.001). Multivariate logistic regression verified CDI as a risk factor of developing depressive symptoms (OR = 6.160, p = 0.001). Conclusion: QoL of patients with craniopharyngioma was remarkably compromised before operation. CDI exerted detrimental influences on patients’ QoL and it might serve as a marker for early identification of patients at risk of depression. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2359-4292 |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024000100315&lng=en&tlng=enTest; http://www.scielo.br/pdf/aem/v68/2359-4292-aem-68-e230001.pdfTest; https://doaj.org/toc/2359-4292Test |
| DOI: | 10.20945/2359-4292-2023-0001 |
| الوصول الحر: | https://doaj.org/article/9a9c16de479c4381ac449cf692992432Test |
| رقم الانضمام: | edsdoj.9a9c16de479c4381ac449cf692992432 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23594292 |
|---|---|
| DOI: | 10.20945/2359-4292-2023-0001 |