دورية أكاديمية
Real-World Effectiveness of Single-Inhaler Triple Therapy for COPD: Impact of Diabetes Comorbidity
| العنوان: | Real-World Effectiveness of Single-Inhaler Triple Therapy for COPD: Impact of Diabetes Comorbidity |
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| المؤلفون: | Sophia Eilat-Tsanani, Pierre Ernst, Samy Suissa |
| المصدر: | COPD, Vol 21, Iss 1 (2024) |
| بيانات النشر: | Taylor & Francis Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | Cohort studies, COPD exacerbation, multimorbidity, propensity scores, real-world evidence, Diseases of the respiratory system, RC705-779 |
| الوصف: | AbstractBackground Type 2 diabetes is a frequent comorbidity in chronic obstructive pulmonary disease (COPD) patients, with the GOLD treatment recommendations asserting that the presence of diabetes be disregarded in the choice of treatment.Methods In a cohort of COPD patients with frequent exacerbations, initiators of single-inhaler triple therapy or dual bronchodilators were compared on the incidence of COPD exacerbation and pneumonia over one year, adjusted by propensity score weighting and stratified by type 2 diabetes.Results The COPD cohort included 1,114 initiators of triple inhalers and 4,233 of dual bronchodilators (28% with type 2 diabetes). The adjusted hazard ratio (HR) of exacerbation with triple therapy was 1.04 (95% CI: 0.86–1.25) among COPD patients with type 2 diabetes and 0.74 (0.65–0.85) in those without. The incidence of severe pneumonia was elevated with triple therapy among patients with type 2 diabetes (HR 1.77; 1.14–2.75).Conclusion Triple therapy in COPD is effective among those without, but not those with, type 2 diabetes. Future therapeutic trials in COPD should consider diabetes comorbidity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 15412555 1541-2563 1541-2555 |
| العلاقة: | https://doaj.org/toc/1541-2555Test; https://doaj.org/toc/1541-2563Test |
| DOI: | 10.1080/15412555.2024.2327345 |
| الوصول الحر: | https://doaj.org/article/9a238951bca04b54b5c397a2f67517c5Test |
| رقم الانضمام: | edsdoj.9a238951bca04b54b5c397a2f67517c5 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 15412555 15412563 |
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| DOI: | 10.1080/15412555.2024.2327345 |