دورية أكاديمية
أعرض في EDS

Reliability and variation in mitochondrial respiration in human adipose tissue

التفاصيل البيبلوغرافية
العنوان: Reliability and variation in mitochondrial respiration in human adipose tissue
المؤلفون: Ronni Eg Sahl, Eva Frederikke Høy Helms, Malte Schmücker, Mathias Flensted-Jensen, Arthur Ingersen, Thomas Morville, Flemming Dela, Jørn Wulff Helge, Steen Larsen
المصدر: Adipocyte, Vol 10, Iss 1, Pp 605-611 (2021)
بيانات النشر: Taylor & Francis Group, 2021.
سنة النشر: 2021
المجموعة: LCC:Diseases of the endocrine glands. Clinical endocrinology
LCC:Cytology
LCC:Physiology
مصطلحات موضوعية: adipose tissue, human, mitochondria, high resolution respirometry, coefficient of variation, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Cytology, QH573-671, Physiology, QP1-981
الوصف: Adipose tissue mitochondrial function is gaining increasing interest since it is a good marker of overall health. Methodological challenges and variability in assessing mitochondrial respiration in fresh adipose tissue with high-resolution respirometry are unknown and should be explored. Mitochondrial respiratory capacity (MRC) in human adipose tissue declines in a gradual manner when analyses are postponed 3 h and 24 h, with a statistically significant decline 24 h after obtaining the biopsy. This decline in MRC is associated with a reduced integrity of the outer mitochondrial membrane at both time points. This study suggests that the optimal amount of tissue to be used is 20 mg and that different technicians handling the biopsy do not affect MRC.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2162-3945
2162-397X
21623945
العلاقة: https://doaj.org/toc/2162-3945Test; https://doaj.org/toc/2162-397XTest
DOI: 10.1080/21623945.2021.1991617
الوصول الحر: https://doaj.org/article/99a290dd0b034b6082c2a88f46948afaTest
رقم الانضمام: edsdoj.99a290dd0b034b6082c2a88f46948afa
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21623945
2162397X
DOI:10.1080/21623945.2021.1991617