دورية أكاديمية
ATM polymorphisms IVS24-9delT, IVS38-8T>C, and 5557G>A in Mexican women with familial and/or early-onset breast cancer
| العنوان: | ATM polymorphisms IVS24-9delT, IVS38-8T>C, and 5557G>A in Mexican women with familial and/or early-onset breast cancer |
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| المؤلفون: | Fabiola del Carmen Calderón-Zúñiga, Guadalupe Ocampo-Gómez, Francisco Carlos López-Márquez, Rogelio Recio-Vega, Luis Benjamín Serrano-Gallardo, Pablo Ruiz-Flores |
| المصدر: | Salud Pública de México, Vol 56, Iss 2, Pp 206-212 (2014) |
| بيانات النشر: | Instituto Nacional de Salud Pública, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Public aspects of medicine |
| مصطلحات موضوعية: | ataxia telangiectasia mutated (ATM), breast cancer, single nucleotide polymorphisms (SNP), Public aspects of medicine, RA1-1270 |
| الوصف: | Objective. To assess whether in Mexican population the frequencies of ATM polymorphisms IVS24-9delT, IVS38-8T mayor que C, and 5557G mayor que A in breast cancer (BC) cases and healthy controls were different from those found in other countries. Materials and methods. Frequencies of polymorphisms conferring BC risk IVS24-9delT, IVS38-8T mayor que C, and 5557G mayor que A were analyzed by PCR-RFLP in 94 patients with familial and/or early onset BC, and 97 healthy controls randomly selected. Allele frequencies analysis was done using χ2 and Hardy-Weinberg test. Results. Frequencies of heterozygous were: for 5557G mayor que A, 13% cases, 0%controls (p=0.0009); for IVS24-9delT, 21% cases, 8% controls (p=0.0122); for IVS38-8T mayor que C, only one case. 5557G mayor que A and IVS24-9delT were more frequent in cases than in controls. The allelic frequencies found in 5557G mayor que A are similar to those described by González-Hormazábal in Chile. Conclusion. The similarity of results in this polymorphism between Chilean and Mexican populations may be due to both being crossbred with an Amerindian-Spanish component, while differences may be due to fact that Chilean population has a greater European component than Mexican’s. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian |
| تدمد: | 0036-3634 1606-7916 |
| العلاقة: | http://www.saludpublica.mx/index.php/spm/article/view/7336Test; https://doaj.org/toc/0036-3634Test; https://doaj.org/toc/1606-7916Test |
| DOI: | 10.21149/spm.v56i2.7336 |
| الوصول الحر: | https://doaj.org/article/e98b321fd885442b90845f3d0f368b09Test |
| رقم الانضمام: | edsdoj.98b321fd885442b90845f3d0f368b09 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00363634 16067916 |
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| DOI: | 10.21149/spm.v56i2.7336 |