دورية أكاديمية
Diagnostic and Prognostic Role of CD93 in Cardiovascular Disease: A Systematic Review
| العنوان: | Diagnostic and Prognostic Role of CD93 in Cardiovascular Disease: A Systematic Review |
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| المؤلفون: | Federica Piani, Giovanni Tossetta, Gabriel Cara-Fuentes, Davide Agnoletti, Daniela Marzioni, Claudio Borghi |
| المصدر: | Biomolecules, Vol 13, Iss 6, p 910 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Microbiology |
| مصطلحات موضوعية: | CD93, C1qR1, C1qRp, complement protein 1 q subcomponent receptor, cardiovascular disease, cardiovascular risk factors, Microbiology, QR1-502 |
| الوصف: | Introduction. Cluster of Differentiation (CD) 93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp) is a transmembrane glycoprotein that can also be present in a soluble (sCD93) form. Recent studies have investigated the role of this protein in cardiovascular disease (CVD). The present systematic review aims to assess the associations between CD93 and cardiovascular (CV) risk factors and disease at both the proteomic and genomic levels. Methods. We conducted systematic searches in the PubMed, EMBASE, and Web of Science databases to identify all human studies since inception to February 2023 that investigated the role of CD93 in CV risk factors, CVD, and CV-associated outcomes. The data collection and analysis have been independently conducted by two reviewers. The search terms included: cardiovascular, heart failure, acute stroke, myocardial infarction, stroke, peripheral artery disease, cardiovascular death, MACE, hypertension, metabolic syndrome, hyperuricemia, diabetes, cd93, c1qr, C1qR1, complement protein 1 q subcomponent receptor. Results. A total of 182 references were identified, and 15 studies investigating the associations between CD93 protein levels or CD93 genetic polymorphisms and the development or prevalence of CV risk factors (i.e., hypertension, dyslipidemia, and obesity) and CVD (i.e., heart failure, coronary artery disease, and ischemic stroke) were included. Although promising, the quality and dimension of the analyzed studies do not allow for a definitive answer to the question of whether CD93 may hold diagnostic and prognostic value in CVD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13060910 2218-273X |
| العلاقة: | https://www.mdpi.com/2218-273X/13/6/910Test; https://doaj.org/toc/2218-273XTest |
| DOI: | 10.3390/biom13060910 |
| الوصول الحر: | https://doaj.org/article/d97d47d66ebc421b8309dde7ce0d6707Test |
| رقم الانضمام: | edsdoj.97d47d66ebc421b8309dde7ce0d6707 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13060910 2218273X |
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| DOI: | 10.3390/biom13060910 |