دورية أكاديمية
Local-scale phylodynamics reveal differential community impact of SARS-CoV-2 in a metropolitan US county.
| العنوان: | Local-scale phylodynamics reveal differential community impact of SARS-CoV-2 in a metropolitan US county. |
|---|---|
| المؤلفون: | Miguel I Paredes, Amanda C Perofsky, Lauren Frisbie, Louise H Moncla, Pavitra Roychoudhury, Hong Xie, Shah A Mohamed Bakhash, Kevin Kong, Isabel Arnould, Tien V Nguyen, Seffir T Wendm, Pooneh Hajian, Sean Ellis, Patrick C Mathias, Alexander L Greninger, Lea M Starita, Chris D Frazar, Erica Ryke, Weizhi Zhong, Luis Gamboa, Machiko Threlkeld, Jover Lee, Jeremy Stone, Evan McDermot, Melissa Truong, Jay Shendure, Hanna N Oltean, Cécile Viboud, Helen Chu, Nicola F Müller, Trevor Bedford |
| المصدر: | PLoS Pathogens, Vol 20, Iss 3, p e1012117 (2024) |
| بيانات النشر: | Public Library of Science (PLoS), 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Biology (General) |
| مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5 |
| الوصف: | SARS-CoV-2 transmission is largely driven by heterogeneous dynamics at a local scale, leaving local health departments to design interventions with limited information. We analyzed SARS-CoV-2 genomes sampled between February 2020 and March 2022 jointly with epidemiological and cell phone mobility data to investigate fine scale spatiotemporal SARS-CoV-2 transmission dynamics in King County, Washington, a diverse, metropolitan US county. We applied an approximate structured coalescent approach to model transmission within and between North King County and South King County alongside the rate of outside introductions into the county. Our phylodynamic analyses reveal that following stay-at-home orders, the epidemic trajectories of North and South King County began to diverge. We find that South King County consistently had more reported and estimated cases, COVID-19 hospitalizations, and longer persistence of local viral transmission when compared to North King County, where viral importations from outside drove a larger proportion of new cases. Using mobility and demographic data, we also find that South King County experienced a more modest and less sustained reduction in mobility following stay-at-home orders than North King County, while also bearing more socioeconomic inequities that might contribute to a disproportionate burden of SARS-CoV-2 transmission. Overall, our findings suggest a role for local-scale phylodynamics in understanding the heterogeneous transmission landscape. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1553-7366 1553-7374 |
| العلاقة: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012117&type=printableTest; https://doaj.org/toc/1553-7366Test; https://doaj.org/toc/1553-7374Test |
| DOI: | 10.1371/journal.ppat.1012117&type=printable |
| DOI: | 10.1371/journal.ppat.1012117 |
| الوصول الحر: | https://doaj.org/article/969775afc55a4a1ba6bff822d4c59f3fTest |
| رقم الانضمام: | edsdoj.969775afc55a4a1ba6bff822d4c59f3f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15537366 15537374 |
|---|---|
| DOI: | 10.1371/journal.ppat.1012117&type=printable |