دورية أكاديمية
Vascular mechanisms leading to progression of mild cognitive impairment to dementia after COVID-19: Protocol and methodology of a prospective longitudinal observational study.
| العنوان: | Vascular mechanisms leading to progression of mild cognitive impairment to dementia after COVID-19: Protocol and methodology of a prospective longitudinal observational study. |
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| المؤلفون: | Cameron D Owens, Camila Bonin Pinto, Peter Mukli, Zsofia Szarvas, Anna Peterfi, Sam Detwiler, Lauren Olay, Ann L Olson, Guangpu Li, Veronica Galvan, Angelia C Kirkpatrick, Priya Balasubramanian, Stefano Tarantini, Anna Csiszar, Zoltan Ungvari, Calin I Prodan, Andriy Yabluchanskiy |
| المصدر: | PLoS ONE, Vol 18, Iss 8, p e0289508 (2023) |
| بيانات النشر: | Public Library of Science (PLoS), 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | IntroductionMild cognitive impairment (MCI) is a prodromal stage to dementia, affecting up to 20% of the aging population worldwide. Patients with MCI have an annual conversion rate to dementia of 15-20%. Thus, conditions that increase the conversion from MCI to dementia are of the utmost public health concern. The COVID-19 pandemic poses a significant impact on our aging population with cognitive decline as one of the leading complications following recovery from acute infection. Recent findings suggest that COVID-19 increases the conversion rate from MCI to dementia in older adults. Hence, we aim to uncover a mechanism for COVID-19 induced cognitive impairment and progression to dementia to pave the way for future therapeutic targets that may mitigate COVID-19 induced cognitive decline.MethodologyA prospective longitudinal study is conducted at the University of Oklahoma Health Sciences Center. Patients are screened in the Department of Neurology and must have a formal diagnosis of MCI, and MRI imaging prior to study enrollment. Patients who meet the inclusion criteria are enrolled and followed-up at 18-months after their first visit. Visit one and 18-month follow-up will include an integrated and cohesive battery of vascular and cognitive measurements, including peripheral endothelial function (flow-mediated dilation, laser speckle contrast imaging), retinal and cerebrovascular hemodynamics (dynamic vessel retinal analysis, functional near-infrared spectroscopy), and fluid and crystalized intelligence (NIH-Toolbox, n-back). Multiple logistic regression will be used for primary longitudinal data analysis to determine whether COVID-19 related impairment in neurovascular coupling and increases in white matter hyperintensity burden contribute to progression to dementia. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0289508&type=printableTest; https://doaj.org/toc/1932-6203Test |
| DOI: | 10.1371/journal.pone.0289508&type=printable |
| DOI: | 10.1371/journal.pone.0289508 |
| الوصول الحر: | https://doaj.org/article/95f0742d01e5478282663ff48c3ad94fTest |
| رقم الانضمام: | edsdoj.95f0742d01e5478282663ff48c3ad94f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0289508&type=printable |