دورية أكاديمية
Correlation of an Index-Lesion-Based SPECT Dosimetry Method with Mean Tumor Dose and Clinical Outcome after 177Lu-PSMA-617 Radioligand Therapy
| العنوان: | Correlation of an Index-Lesion-Based SPECT Dosimetry Method with Mean Tumor Dose and Clinical Outcome after 177Lu-PSMA-617 Radioligand Therapy |
|---|---|
| المؤلفون: | Friederike Völter, Lena Mittlmeier, Astrid Gosewisch, Julia Brosch-Lenz, Franz Josef Gildehaus, Mathias Johannes Zacherl, Leonie Beyer, Christian G. Stief, Adrien Holzgreve, Johannes Rübenthaler, Clemens C. Cyran, Guido Böning, Peter Bartenstein, Andrei Todica, Harun Ilhan |
| المصدر: | Diagnostics, Vol 11, Iss 3, p 428 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | radioligand therapy, 177Lu-PSMA, dosimetry, SPECT, mCRPC, Medicine (General), R5-920 |
| الوصف: | Background: Dosimetry can tailor prostate-specific membrane-antigen-targeted radioligand therapy (PSMA-RLT) for metastatic castration-resistant prostate cancer (mCRPC). However, whole-body tumor dosimetry is challenging in patients with a high tumor burden. We evaluate a simplified index-lesion-based single-photon emission computed tomography (SPECT) dosimetry method in correlation with clinical outcome. Methods: 30 mCRPC patients were included (median 71 years). The dosimetry was performed for the first cycle using quantitative 177Lu-SPECT. The response was evaluated using RECIST 1.1 and PERCIST criteria, as well as changes in PSMA-positive tumor volume (PSMA-TV) in post-therapy PSMA-PET and biochemical response according to PSA changes after two RLT cycles. Results: Mean tumor doses as well as index-lesion doses were significantly higher in PERCIST responders compared to non-responders (10.2 ± 12.0 Gy/GBq vs. 4.0 ± 2.9 Gy/GBq, p = 0.03 and 13.7 ± 14.2 Gy/GBq vs. 5.9 ± 4.4 Gy/GBq, p = 0.04, respectively). No significant differences in mean tumor and index lesion doses were observed between responders and non-responders according to RECIST 1.1, PSMA-TV, and biochemical response criteria. Conclusion: Compared to mean tumor doses on a patient level, single index-lesion-based SPECT dosimetry correlates equally well with the response to PSMA-RLT according to PERCIST criteria and may represent a fast and feasible dosimetry approach for clinical routine. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2075-4418 94650675 |
| العلاقة: | https://www.mdpi.com/2075-4418/11/3/428Test; https://doaj.org/toc/2075-4418Test |
| DOI: | 10.3390/diagnostics11030428 |
| الوصول الحر: | https://doaj.org/article/9465067559e145b7ba908c6f40a7d0fbTest |
| رقم الانضمام: | edsdoj.9465067559e145b7ba908c6f40a7d0fb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20754418 94650675 |
|---|---|
| DOI: | 10.3390/diagnostics11030428 |