دورية أكاديمية
Recent advances in senescence-associated secretory phenotype and osteoporosis
| العنوان: | Recent advances in senescence-associated secretory phenotype and osteoporosis |
|---|---|
| المؤلفون: | Haonan Fan, Zhi Qiao, Jitian Li, Guowei Shang, Chunfeng Shang, Songfeng Chen, Zikuan Leng, Huifang Su, Hongwei Kou, Hongjian Liu |
| المصدر: | Heliyon, Vol 10, Iss 4, Pp e25538- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Cellular senescence, Osteoporosis, Senescence-associated secretory phenotype (SASP), Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | The worldwide elderly population is on the rise, and aging is a major osteoporosis risk factor. Senescent cells accumulation can have a detrimental effect the body as we age. The senescence-associated secretory phenotype (SASP), an essential cellular senescence hallmark, is an important mechanism connecting cellular senescence to osteoporosis. This review describes in detail the characteristics of SASPs and their regulatory agencies, and shed fresh light on how SASPs from different senescent cells contribute to osteoporosis development. Furthermore, we summarized various innovative therapy techniques that target SASPs to lower the burden of osteoporosis in the elderly and discussed the potential challenges of SASPs-based therapy for osteoporosis as a new clinical trial. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S240584402401569XTest; https://doaj.org/toc/2405-8440Test |
| DOI: | 10.1016/j.heliyon.2024.e25538 |
| الوصول الحر: | https://doaj.org/article/93ee55ed4f9f4a1a8b5781e8eaab9efcTest |
| رقم الانضمام: | edsdoj.93ee55ed4f9f4a1a8b5781e8eaab9efc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
|---|---|
| DOI: | 10.1016/j.heliyon.2024.e25538 |