Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity

التفاصيل البيبلوغرافية
العنوان:	Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity
المؤلفون:	Reuben Franklin, Yiming Guo, Shiyang He, Meijuan Chen, Fei Ji, Xinyue Zhou, David Frankhouser, Brian T. Do, Carmen Chiem, Mihyun Jang, M. Andres Blanco, Matthew G. Vander Heiden, Russell C. Rockne, Maria Ninova, David B. Sykes, Konrad Hochedlinger, Rui Lu, Ruslan I. Sadreyev, Jernej Murn, Andrew Volk, Sihem Cheloufi
المصدر:	Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
بيانات النشر:	Nature Portfolio, 2022.
سنة النشر:	2022
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Cell fate commitment involves transcription factor activity and changes in chromatin architecture. Here the authors show that CAF-1 maintains lineage fidelity by controlling chromatin accessibility at specific sites; suppressing CAF-1 triggers differentiation of myeloid stem and progenitor cells into a mixed lineage state.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
العلاقة:	https://doaj.org/toc/2041-1723Test
DOI:	10.1038/s41467-022-29730-6
الوصول الحر:	https://doaj.org/article/92b1277f52324a2d9ee446b86d5f55ddTest
رقم الانضمام:	edsdoj.92b1277f52324a2d9ee446b86d5f55dd
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-022-29730-6