دورية أكاديمية
Curative effects of tectochrysin on paraquat-instigated testicular toxicity in rats: A biochemical and histopathological based study
| العنوان: | Curative effects of tectochrysin on paraquat-instigated testicular toxicity in rats: A biochemical and histopathological based study |
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| المؤلفون: | Muhammad Umar Ijaz, Kaynat Alvi, Ali Hamza, Haseeb Anwar, Khalid A. Al-Ghanim, Mian Nadeem Riaz |
| المصدر: | Heliyon, Vol 10, Iss 3, Pp e25337- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Paraquat, Tectochrysin, Testicular tissues, Steroidogenic enzymes, Inflammatory markers, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Background: Paraquat (PQ) is a herbicide that is used globally in the agriculture sector to eradicate unwanted weeds, however it also induces significant damages in various organs of the body such as testes. Tectochrysin (TEC) is an important flavonoid that shows versatile therapeutic potentials. Currently, there is no established antidote to cure PQ-induced testicular toxicity. Objective: The present study was conducted to evaluate the ameliorative effects of TEC against PQ prompted testicular damage. Methods: Sprague-Dawley rats (n = 48) were used to conduct the trial. Rats were allocated in to 4 groups i.e., Control, PQ administrated group (5 mgkg−1), PQ + TEC co-administrated group (5 mgkg−1 + 2.5 mgkg−1) and TEC only administrated group (2.5 mgkg−1). The trial was conducted for 8 weeks. The activity of anti-oxidants and the levels of MDA and ROS were determined by spectrophotometric method. Steroidogenic enzymes as well as apoptotic markers expressions were evaluated by qRT-PCR. The level of hormones and inflammatory indices was quantified by enzyme-linked immunosorbent assay. Results: PQ exposure markedly (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2405844024013689Test; https://doaj.org/toc/2405-8440Test |
| DOI: | 10.1016/j.heliyon.2024.e25337 |
| الوصول الحر: | https://doaj.org/article/926fcbcdecee4a19a4225e1b41c7decdTest |
| رقم الانضمام: | edsdoj.926fcbcdecee4a19a4225e1b41c7decd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e25337 |