دورية أكاديمية
Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
| العنوان: | Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress |
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| المؤلفون: | Marina A. Forrellad, Cristina L. Vázquez, Federico C. Blanco, Laura I. Klepp, Elizabeth A. García, Rosana V. Rocha, Villafañe Luciana, María M. Bigi, Maximiliano G. Gutierrez, Fabiana Bigi |
| المصدر: | Virulence, Vol 10, Iss 1, Pp 1026-1033 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | mycobacterium tuberculosis, oxidative stress, virulence factor, rv2617c, erp, Infectious and parasitic diseases, RC109-216 |
| الوصف: | In this study, we characterized the role of Rv2617c in the virulence of Mycobacterium tuberculosis. Rv2617c is a protein of unknown function unique to M. tuberculosis complex (MTC) and Mycobacterium leprae. In vitro, this protein interacts with the virulence factor P36 (also named Erp) and KdpF, a protein linked to nitrosative stress. Here, we showed that knockout of the Rv2617c gene in M. tuberculosis CDC1551 reduced the replication of the pathogen in a mouse model of infection and favored the trafficking of mycobacteria to phagolysosomes. We also demonstrated that Rv2617c and P36 are required for resistance to in vitro hydrogen peroxide treatment in M. tuberculosis and Mycobacterium bovis, respectively. These findings indicate Rv2617c and P36 act in concert to prevent bacterial damage upon oxidative stress. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2150-5594 2150-5608 21505594 |
| العلاقة: | https://doaj.org/toc/2150-5594Test; https://doaj.org/toc/2150-5608Test |
| DOI: | 10.1080/21505594.2019.1693714 |
| الوصول الحر: | https://doaj.org/article/9240374c58df4e1ca84a4178b78e37bcTest |
| رقم الانضمام: | edsdoj.9240374c58df4e1ca84a4178b78e37bc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21505594 21505608 |
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| DOI: | 10.1080/21505594.2019.1693714 |