دورية أكاديمية
Expression of Leptin Receptor and Effects of Leptin on Papillary Thyroid Carcinoma Cells
| العنوان: | Expression of Leptin Receptor and Effects of Leptin on Papillary Thyroid Carcinoma Cells |
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| المؤلفون: | Marilena Celano, Valentina Maggisano, Saverio Massimo Lepore, Marialuisa Sponziello, Valeria Pecce, Antonella Verrienti, Cosimo Durante, Marianna Maranghi, Piernatale Lucia, Stefania Bulotta, Giuseppe Damante, Diego Russo |
| المصدر: | International Journal of Endocrinology, Vol 2019 (2019) |
| بيانات النشر: | Hindawi Limited, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Background. Obesity has been hypothesized to contribute to the aggressiveness of thyroid cancer through the production of abnormal levels of serum adipokines. Leptin receptor (OB-R) expression has also been documented in papillary thyroid cancer (PTC). Aim. In this translational study, we analyzed in vitro the effects of leptin on the growth and migration of thyroid cancer cells (TPC-1 and K1), the molecular mechanisms underlying leptin’s action, and the influence of prolonged leptin exposure on cell response to a protein kinase inhibitor lenvatinib. The expression levels of OB-R mRNA and protein were also investigated in vivo in a series of aggressive PTCs divided into two groups based on the presence of the BRAF mutation. Results. In TPC-1 and K1 cells, prolonged treatment with leptin (500 ng/ml for 96 h) resulted in a mild increase in the proliferation (about 20% over control only in K1 cells, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-8337 1687-8345 |
| العلاقة: | https://doaj.org/toc/1687-8337Test; https://doaj.org/toc/1687-8345Test |
| DOI: | 10.1155/2019/5031696 |
| الوصول الحر: | https://doaj.org/article/922a5c76e57b47f1aac04576ac75ad86Test |
| رقم الانضمام: | edsdoj.922a5c76e57b47f1aac04576ac75ad86 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16878337 16878345 |
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| DOI: | 10.1155/2019/5031696 |