دورية أكاديمية
أعرض في EDS

Effects of the factor V G1691A mutation and the factor II G20210A variant on the clinical expression of severe hemophilia A in children – results of a multicenter study

التفاصيل البيبلوغرافية
العنوان: Effects of the factor V G1691A mutation and the factor II G20210A variant on the clinical expression of severe hemophilia A in children – results of a multicenter study
المؤلفون: Karin Kurnik, Wolfhart Kreuz, Sylvia Horneff, Christine Düring, Rosemarie Schobess, Christoph Bidlingmaier, Carmen Escuriola Ettingshausen, Anne Krümpel, Nadia Bogdanova, Ulrike Nowak-Göttl
المصدر: Haematologica, Vol 92, Iss 7 (2007)
بيانات النشر: Ferrata Storti Foundation, 2007.
سنة النشر: 2007
المجموعة: LCC:Diseases of the blood and blood-forming organs
مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5
الوصف: The present multicenter cohort study of 107 pediatric PUPs was performed to determine whether the concomitant inheritance of the factor (F) V G1691A or the F II G20210A mutation influences the clinical expression of severe hemophilia A (HA). Carriers of the FV and FII mutations had a significantly lower annual bleeding frequency (ABF) than non-carriers (p=0.012). Joint damage (Pettersson score) was significantly less severe in patients with thrombophilia (p=0.022). A protective effect of thrombophilic risk factors was shown for ABF (OR [CIs]: 0.7[0.5–0.9]; p=0.02) and the severity of the hemophilic arthropathy (OR [CIs]: 0.06[0.01–0.3]; p=0.0009).
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0390-6078
1592-8721
العلاقة: https://haematologica.org/article/view/4516Test; https://doaj.org/toc/0390-6078Test; https://doaj.org/toc/1592-8721Test
DOI: 10.3324/haematol.11161
الوصول الحر: https://doaj.org/article/90d90ab52b3f4a3ba5bbad9c87878ffaTest
رقم الانضمام: edsdoj.90d90ab52b3f4a3ba5bbad9c87878ffa
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:03906078
15928721
DOI:10.3324/haematol.11161