دورية أكاديمية
Approaches towards Longevity: Reprogramming, Senolysis, and Improved Mitotic Competence as Anti-Aging Therapies
العنوان: | Approaches towards Longevity: Reprogramming, Senolysis, and Improved Mitotic Competence as Anti-Aging Therapies |
---|---|
المؤلفون: | Sofia Melo Pereira, Rui Ribeiro, Elsa Logarinho |
المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 4, p 938 (2019) |
بيانات النشر: | MDPI AG, 2019. |
سنة النشر: | 2019 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | aging, cellular senescence, cellular reprogramming, cell cycle fitness, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Mainstream approaches that are currently used as anti-aging therapies primarily explore the senescence and epigenetic drift aging hallmarks and they are at two ends of the spectrum. While senolytic therapies include either the selective elimination of senescent cells or the disruption of their secretome with the use of drugs or natural compounds, cellular reprogramming uses genetic manipulation to revert cells all the way back to pluripotency. Here, we describe the progress that has been made on these therapies, while highlighting the major challenges involved. Moreover, based on recent findings elucidating the impact of mitotic shutdown and aneuploidy in cellular senescence, we discuss the modulation of mitotic competence as an alternative strategy to delay the hallmarks of aging. We propose that a regulated rise in mitotic competence of cells could circumvent certain limitations that are present in the senolytic and reprogramming approaches, by acting to decelerate senescence and possibly restore the epigenetic landscape. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 20040938 |
العلاقة: | https://www.mdpi.com/1422-0067/20/4/938Test; https://doaj.org/toc/1422-0067Test |
DOI: | 10.3390/ijms20040938 |
الوصول الحر: | https://doaj.org/article/909a3f8a1b14426cbf20a390445d0a25Test |
رقم الانضمام: | edsdoj.909a3f8a1b14426cbf20a390445d0a25 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 20040938 |
---|---|
DOI: | 10.3390/ijms20040938 |