دورية أكاديمية
The effectiveness of eradication therapy of the 1st line of Helicobacter pylori infection in patients with type 2 diabetes mellitus
| العنوان: | The effectiveness of eradication therapy of the 1st line of Helicobacter pylori infection in patients with type 2 diabetes mellitus |
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| المؤلفون: | Igor V. Maev, Ashot M. Mkrtumyan, Luiza G. Bektemirova, Dmitry N. Andreev, Diana T. Dicheva |
| المصدر: | Терапевтический архив, Vol 94, Iss 2, Pp 209-215 (2022) |
| بيانات النشر: | "Consilium Medicum" Publishing house, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | helicobacter pylori infection, eradication therapy, diabetes mellitus, efficacy of eradication therapy, simultaneous therapy, Medicine |
| الوصف: | Aim. Evaluation of the efficacy and safety of eradication therapy of infection Helicobacter pylori in patients with H. pylori- associated pathology of the upper gastrointestinal tract and concomitant type 2 diabetes mellitus (DM). Materials and methods. The prospective randomized study involving 180 patients (87 men and 93 women) with H. pylori- associated pathology of the upper gastrointestinal tract was carried out. The patients were divided into four groups of 45 people: 1 patients without diabetes who received the classic triple eradication therapy; 2 patients with type 2 DM who received the classic triple eradication therapy; 3 patients without DM who underwent quadrotherapy with bismuth preparations; 4 patients with type 2 DM who underwent quadrotherapy with bismuth preparations. Eradication therapy was carried out for 14 days. Evaluation of the effectiveness of eradication using a breath test was carried out 4 weeks after completion of the course of treatment. Eradication success was assessed separately for ITT and PP analyzes. Results. The effectiveness of classical triple eradication therapy in patients with concomitant type 2 DM is 64.4% in the ITT group and 69.05% in the PP: quadrotherapy 73.34 and 80.49%, respectively. The effectiveness of first line eradication therapy is higher in patients without DM compared with groups of patients with concomitant type 2 DM: ITT 83.33%, PP 88.23% and ITT 68.89%, PP 74.70%, respectively. The incidence of side effects in patients with type 2 DM: with the use of classical triple therapy 22.23%, quadrotherapy 31.12%. Conclusion. The data of the study of the efficacy and safety of line I eradication therapy make it possible to recommend the four-component therapy based on bismuth for use in clinical practice, especially in patients with DM. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 0040-3660 2309-5342 00403660 |
| العلاقة: | https://ter-arkhiv.ru/0040-3660/article/viewFile/105560/79976Test; https://doaj.org/toc/0040-3660Test; https://doaj.org/toc/2309-5342Test |
| DOI: | 10.26442/00403660.2022.02.201372 |
| الوصول الحر: | https://doaj.org/article/90086d93d5204a3ba3c7ccc8b030d636Test |
| رقم الانضمام: | edsdoj.90086d93d5204a3ba3c7ccc8b030d636 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 00403660 23095342 |
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| DOI: | 10.26442/00403660.2022.02.201372 |