دورية أكاديمية
Depth of invasion to the bladder wall as a prognostic factor and its association with circulating cell-free DNA levels in patients with muscle-invasive bladder cancer
| العنوان: | Depth of invasion to the bladder wall as a prognostic factor and its association with circulating cell-free DNA levels in patients with muscle-invasive bladder cancer |
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| المؤلفون: | Yusuke Iemura, Makito Miyake, Shinji Fukui, Tomomi Fujii, Sayuri Ohnishi, Shunta Hori, Yosuke Morizawa, Yasushi Nakai, Kazumasa Torimoto, Nobumichi Tanaka, Kiyohide Fujimoto |
| المصدر: | Current Urology, Vol 17, Iss 4, Pp 229-235 (2023) |
| بيانات النشر: | Wolters Kluwer Health, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Abstract. Background. Radical cystectomy (RC) is the standard surgical treatment for patients with muscle-invasive bladder cancer, but the prognosis is not favorable, and new prognostic factors need to be discovered. We investigated the potential of depth of invasion (DOI) as a prognostic factor in patients with muscle-invasive bladder cancer who underwent RC. Furthermore, we examined the association between preoperative levels of circulating cell-free DNA and DOI. Materials and methods. We retrospectively reviewed patients who underwent RC between January 2007 and December 2017; those who received neoadjuvant chemotherapy were excluded. Depth of invasion was measured using hematoxylin-eosin–stained RC specimens. Results. Of the 121 patients selected, 41 (33.9%) were eligible for analysis. The median follow-up period was 14 months and mean DOI was 17 mm (range, 2–75 mm). Long DOI (>17 mm) was significantly associated with shorter progression-free survival (hazard ratio, 14.5; 95% confidence interval, 3.9–53.97, p < 0.0001) and cancer-specific survival (hazard ratio, 18.97; 95% confidence interval, 4.04–88.99, p = 0.0002) compared with short DOI. Multivariate analysis revealed that DOI was an independent risk factor for cancer-specific survival. The levels of circulating cell-free DNA were significantly higher in patients with a longer DOI than in those with short DOI (65 vs. 20 ng/mL, respectively; p = 0.028). Conclusions. Depth of invasion predicted with levels of circulating cell-free DNA and thus could be a useful prognostic factor. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1661-7649 00000000 |
| العلاقة: | http://journals.lww.com/10.1097/CU9.0000000000000193Test; https://doaj.org/toc/1661-7649Test |
| DOI: | 10.1097/CU9.0000000000000193 |
| الوصول الحر: | https://doaj.org/article/8f8af00d9f764054a2fe44f949cdd66eTest |
| رقم الانضمام: | edsdoj.8f8af00d9f764054a2fe44f949cdd66e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16617649 00000000 |
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| DOI: | 10.1097/CU9.0000000000000193 |