دورية أكاديمية
Emerging role of hypertrophic chondrocytes in tissue regeneration and fracture healing: a narrative review
| العنوان: | Emerging role of hypertrophic chondrocytes in tissue regeneration and fracture healing: a narrative review |
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| المؤلفون: | DY Zhu, G Li, HY Fang, YS Gao |
| المصدر: | European Cells & Materials, Vol 47, Pp 219-237 (2024) |
| بيانات النشر: | Forum Multimedia Publishing LLC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the musculoskeletal system LCC:Orthopedic surgery |
| مصطلحات موضوعية: | hypertrophic chondrocytes, fracture healing, tissue regeneration, endochondral bone formation, developmental engineering, transdifferentiation, Diseases of the musculoskeletal system, RC925-935, Orthopedic surgery, RD701-811 |
| الوصف: | Fracture healing is a complex event that involves the coordination of various different processes, including intramembranous and endochondral bone formation. When facing fracture nonunion or delayed union, few organizational engineering structures can achieve the desired results. The main reason for this is that they cannot recapitulate the cellular morphology, biology, and mechanical functions of natural tissues. Ten years ago, the term Development Engineering was coined to refer to the use of developmental processes as a blueprint for designing and developing engineered live implants. Different sources of cells have been used as seed cells in developmental engineering. Among them, hypertrophic chondrocytes have attracted worldwide attention. Hypertrophic chondrocytes are the terminal state of growth plate chondrocytes, leading to degenerative maturation. Hypertrophic chondrocytes mediate crosstalk by regulating cell-matrix degradation, vascularization, osteoclast recruitment, and osteoblast differentiation. Furthermore, hypertrophic chondrocytes can transdifferentiate into osteoprogenitors and mature osteoblasts, and directly promote woven bone formation. In summary, elucidating the role of hypertrophic chondrocytes will contribute to understand of the physiological mechanism of fracture healing, research and development of novel therapeutic modes of developmental engineering, and further promotion of fracture healing. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1473-2262 |
| العلاقة: | https://www.ecmjournal.org/papers/vol047/vol047a14.phpTest; https://doaj.org/toc/1473-2262Test |
| DOI: | 10.22203/eCM.v047a14 |
| الوصول الحر: | https://doaj.org/article/8d2587089c36471bafa630f880f0dc71Test |
| رقم الانضمام: | edsdoj.8d2587089c36471bafa630f880f0dc71 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14732262 |
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| DOI: | 10.22203/eCM.v047a14 |