دورية أكاديمية
Macrophages at the Crossroad of Meta-Inflammation and Inflammaging
| العنوان: | Macrophages at the Crossroad of Meta-Inflammation and Inflammaging |
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| المؤلفون: | Lili Qu, Alyssa J. Matz, Keaton Karlinsey, Ziming Cao, Anthony T. Vella, Beiyan Zhou |
| المصدر: | Genes, Vol 13, Iss 11, p 2074 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Genetics |
| مصطلحات موضوعية: | macrophage, obesity, aging, meta-inflammation, inflammaging, Genetics, QH426-470 |
| الوصف: | Macrophages are central players in systemic inflammation associated with obesity and aging, termed meta-inflammation and inflammaging. Activities of macrophages elicited by the two chronic conditions display shared and distinct patterns mechanistically, resulting in multifaceted actions for their pathogenic roles. Drastically expanded tissue macrophage populations under obesity and aging stress attribute to both enhanced recruitment and local expansion. Importantly, molecular networks governing the multifaceted actions of macrophages are directly altered by environmental cues and subsequently contribute to metabolic reprogramming, resulting in meta-inflammation in obesity or inflammaging in aging. In this review, we will summarize how meta-inflammation and inflammaging affect macrophages and the molecular mechanisms involved in these processes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13112074 2073-4425 |
| العلاقة: | https://www.mdpi.com/2073-4425/13/11/2074Test; https://doaj.org/toc/2073-4425Test |
| DOI: | 10.3390/genes13112074 |
| الوصول الحر: | https://doaj.org/article/8aad9737e90d43d19d2e2d401594ca10Test |
| رقم الانضمام: | edsdoj.8aad9737e90d43d19d2e2d401594ca10 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13112074 20734425 |
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| DOI: | 10.3390/genes13112074 |