دورية أكاديمية
Anti-Toxin Responses to Natural Enterotoxigenic Escherichia coli (ETEC) Infection in Adults and Children in Bangladesh
| العنوان: | Anti-Toxin Responses to Natural Enterotoxigenic Escherichia coli (ETEC) Infection in Adults and Children in Bangladesh |
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| المؤلفون: | Petra Girardi, Taufiqur Rahman Bhuiyan, Samuel B. Lundin, Shushan Harutyunyan, Irene Neuhauser, Farhana Khanam, Gábor Nagy, Valéria Szijártó, Tamás Henics, Eszter Nagy, Ali M. Harandi, Firdausi Qadri |
| المصدر: | Microorganisms, Vol 11, Iss 10, p 2524 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | ETEC, heat-labile toxin (LT), heat-stable toxin (ST), natural infection, endemic population, children, Biology (General), QH301-705.5 |
| الوصف: | A sero-epidemiology study was conducted in Dhaka, Bangladesh between January 2020 and February 2021 to assess the immune responses to ETEC infection in adults and children. (1) Background: Enterotoxigenic Escherichia coli infection is a main cause of diarrheal disease in endemic countries. The characterization of the immune responses evoked by natural infection can guide vaccine development efforts. (2) Methods: A total of 617 adult and 480 pediatric diarrheal patients were screened, and 43 adults and 46 children (below 5 years of age) with an acute ETEC infection completed the study. The plasma samples were analyzed for antibody responses against the ETEC toxins. (3) Results: Heat-stable toxin (ST)-positive ETEC is the main cause of ETEC infection in adults, unlike in children in an endemic setting. We detected very low levels of anti-ST antibodies, and no ST-neutralizing activity. However, infection with ETEC strains expressing the heat-labile toxin (LT) induced systemic antibody responses in less than 25% of subjects. The antibody levels against LTA and LTB, as well as cholera toxin (CT), correlated well. The anti-LT antibodies were shown to have LT- and CT- neutralizing activity. The antibody reactivity against linear LT epitopes did not correlate with toxin-neutralizing activity. (4) Conclusions: Unlike LT, ST is a poor antigen and even adults have low anti-ST antibody levels that do not allow for the detection of toxin-neutralizing activity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2076-2607 89381564 |
| العلاقة: | https://www.mdpi.com/2076-2607/11/10/2524Test; https://doaj.org/toc/2076-2607Test |
| DOI: | 10.3390/microorganisms11102524 |
| الوصول الحر: | https://doaj.org/article/8938156406c94b0caef3ddffa8612515Test |
| رقم الانضمام: | edsdoj.8938156406c94b0caef3ddffa8612515 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20762607 89381564 |
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| DOI: | 10.3390/microorganisms11102524 |