دورية أكاديمية
Thermal and nonthermal effects of radiofrequency on living state and applications as an adjuvant with radiation therapy
| العنوان: | Thermal and nonthermal effects of radiofrequency on living state and applications as an adjuvant with radiation therapy |
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| المؤلفون: | Andras Szasz |
| المصدر: | Journal of Radiation and Cancer Research, Vol 10, Iss 1, Pp 1-17 (2019) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Abscopal effect, apoptosis, electromagnetic effects, immunogenic cell death, ionizing, modulated electrohyperthermia, oncothermia, radiofrequency current, radiotherapy, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | One of the most frequently applied bioelectromagnetic effects is the deep heating of living species with electromotive force energy. Despite its long history, hyperthermia is a rarely applied oncotherapy because of controversial results and complicated control. The challenge in clinical studies of oncological hyperthermia is the disharmony of the local response and local control with overall survival. Both whole-body (complete isothermia for the body) and local (isothermia for the chosen target) heating show excellent local effects; however, this is not followed with the expected elongation of survival time. A possible solution could be nonisothermal heating to the heterogeneity of the malignancy itself. The distinguishing parameters to select the target are the electromagnetic properties of the malignant tissue together with the physiological differences between malignant cells and their healthy counterparts. Selection could allow for cellular targeting, generating natural reactions, such as programmed cell death (apoptosis) followed by immunogenic cell death involving extended immune reactions. This complex method is a new kind of hyperthermia, named modulated electrohyperthermia (tradename oncothermia). The selective, nonequilibrium energy absorption is well synergized with modern radiation therapies, presenting a solution of an active and controllable tumor-specific immune reaction and subsequent abscopal effects. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2588-9273 2468-9203 |
| العلاقة: | http://www.journalrcr.org/article.asp?issn=2588-9273;year=2019;volume=10;issue=1;spage=1;epage=17;aulast=SzaszTest; https://doaj.org/toc/2588-9273Test; https://doaj.org/toc/2468-9203Test |
| DOI: | 10.4103/jrcr.jrcr_25_18 |
| الوصول الحر: | https://doaj.org/article/85d94aa6c61d49ceb1818c57ced2ddcfTest |
| رقم الانضمام: | edsdoj.85d94aa6c61d49ceb1818c57ced2ddcf |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 25889273 24689203 |
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| DOI: | 10.4103/jrcr.jrcr_25_18 |