دورية أكاديمية
The Hen or the Egg: Impaired Alveolar Oxygen Diffusion and Acute High-altitude Illness?
| العنوان: | The Hen or the Egg: Impaired Alveolar Oxygen Diffusion and Acute High-altitude Illness? |
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| المؤلفون: | Heimo Mairbäurl, Christoph Dehnert, Franziska Macholz, Daniel Dankl, Mahdi Sareban, Marc M. Berger |
| المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 17, p 4105 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | high-altitude pulmonary edema, acute mountain sickness, oxygen diffusion limitation, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Individuals ascending rapidly to altitudes >2500 m may develop symptoms of acute mountain sickness (AMS) within a few hours of arrival and/or high-altitude pulmonary edema (HAPE), which occurs typically during the first three days after reaching altitudes above 3000−3500 m. Both diseases have distinct pathologies, but both present with a pronounced decrease in oxygen saturation of hemoglobin in arterial blood (SO2). This raises the question of mechanisms impairing the diffusion of oxygen (O2) across the alveolar wall and whether the higher degree of hypoxemia is in causal relationship with developing the respective symptoms. In an attempt to answer these questions this article will review factors affecting alveolar gas diffusion, such as alveolar ventilation, the alveolar-to-arterial O2-gradient, and balance between filtration of fluid into the alveolar space and its clearance, and relate them to the respective disease. The resultant analysis reveals that in both AMS and HAPE the main pathophysiologic mechanisms are activated before aggravated decrease in SO2 occurs, indicating that impaired alveolar epithelial function and the resultant diffusion limitation for oxygen may rather be a consequence, not the primary cause, of these altitude-related illnesses. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | https://www.mdpi.com/1422-0067/20/17/4105Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms20174105 |
| الوصول الحر: | https://doaj.org/article/a830a401959c44b99a57ca80b7b3a736Test |
| رقم الانضمام: | edsdoj.830a401959c44b99a57ca80b7b3a736 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms20174105 |