دورية أكاديمية

Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis

التفاصيل البيبلوغرافية
العنوان: Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis
المؤلفون: Teresa Maria Creanza, Maria Liguori, Sabino Liuni, Nicoletta Nuzziello, Nicola Ancona
المصدر: International Journal of Molecular Sciences, Vol 17, Iss 6, p 936 (2016)
بيانات النشر: MDPI AG, 2016.
سنة النشر: 2016
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: gene expression, multiple sclerosis, gene networks, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Differential gene expression analyses to investigate multiple sclerosis (MS) molecular pathogenesis cannot detect genes harboring genetic and/or epigenetic modifications that change the gene functions without affecting their expression. Differential co-expression network approaches may capture changes in functional interactions resulting from these alterations. We re-analyzed 595 mRNA arrays from publicly available datasets by studying changes in gene co-expression networks in MS and in response to interferon (IFN)-β treatment. Interestingly, MS networks show a reduced connectivity relative to the healthy condition, and the treatment activates the transcription of genes and increases their connectivity in MS patients. Importantly, the analysis of changes in gene connectivity in MS patients provides new evidence of association for genes already implicated in MS by single-nucleotide polymorphism studies and that do not show differential expression. This is the case of amiloride-sensitive cation channel 1 neuronal (ACCN1) that shows a reduced number of interacting partners in MS networks, and it is known for its role in synaptic transmission and central nervous system (CNS) development. Furthermore, our study confirms a deregulation of the vitamin D system: among the transcription factors that potentially regulate the deregulated genes, we find TCF3 and SP1 that are both involved in vitamin D3-induced p27Kip1 expression. Unveiling differential network properties allows us to gain systems-level insights into disease mechanisms and may suggest putative targets for the treatment.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
العلاقة: http://www.mdpi.com/1422-0067/17/6/936Test; https://doaj.org/toc/1422-0067Test
DOI: 10.3390/ijms17060936
الوصول الحر: https://doaj.org/article/d7ed2059657f4b3fb069f1736c0c7e04Test
رقم الانضمام: edsdoj.7ed2059657f4b3fb069f1736c0c7e04
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms17060936