Biologically Aggressive Phenotype and Anti-cancer Immunity Counterbalance in Breast Cancer with High Mutation Rate

التفاصيل البيبلوغرافية
العنوان:	Biologically Aggressive Phenotype and Anti-cancer Immunity Counterbalance in Breast Cancer with High Mutation Rate
المؤلفون:	Hideo Takahashi, Mariko Asaoka, Li Yan, Omar M. Rashid, Masanori Oshi, Takashi Ishikawa, Masayuki Nagahashi, Kazuaki Takabe
المصدر:	Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
بيانات النشر:	Nature Portfolio, 2020.
سنة النشر:	2020
المجموعة:	LCC:Medicine LCC:Science
مصطلحات موضوعية:	Medicine, Science
الوصف:	Abstract While cancer cells gain aggressiveness by mutations, abundant mutations release neoantigens, attracting anti-cancer immune cells. We hypothesized that in breast cancer (BC), where mutation is less common, tumors with high mutation rates demonstrate aggressive phenotypes and attract immune cells simultaneously. High mutation rates were defined as the top 10% of the mutation rate, utilizing TCGA and METABRIC transcriptomic data. Mutation rate did not impact survival although high mutation BCs were associated with aggressive clinical features, such as more frequent in ER-negative tumors (p
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2045-2322
العلاقة:	https://doaj.org/toc/2045-2322Test
DOI:	10.1038/s41598-020-58995-4
الوصول الحر:	https://doaj.org/article/7da8c6f6d26c4ed3a1ec4b0f1f4f5d48Test
رقم الانضمام:	edsdoj.7da8c6f6d26c4ed3a1ec4b0f1f4f5d48
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20452322
DOI:	10.1038/s41598-020-58995-4