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Open Reading Frame-3a gene of the 2019 novel coronavirus inhibits the occurrence and development of colorectal cancer

التفاصيل البيبلوغرافية
العنوان: Open Reading Frame-3a gene of the 2019 novel coronavirus inhibits the occurrence and development of colorectal cancer
المؤلفون: Han Shuwen, Wu Yinhang, Mao Jing, Chen Gong, Hou Xiaohui, Yang Xi, Wu Wei
المصدر: Discover Oncology, Vol 13, Iss 1, Pp 1-15 (2022)
بيانات النشر: Springer, 2022.
سنة النشر: 2022
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: 2019-nCoV, ORF3a, Colorectal cancer, Cell viability, Cell cycle, Apoptosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Highlights 1. ORF3a was successfully transfected into SW480 cells, and its expression was localized in the cytoplasm of SW480 cells. 2. ORF3a inhibited SW480 cell proliferation, invasion and migration, induced their apoptosis, and blocked them in the G1 phase. 3. ORF3a inhibited colorectal tumor growth and accelerated cancer cell death in vivo. 4. Our study provides new insights into the use of viruses in anti-tumor regimens in colorectal cancer.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2730-6011
العلاقة: https://doaj.org/toc/2730-6011Test
DOI: 10.1007/s12672-022-00473-6
الوصول الحر: https://doaj.org/article/7c057a3b7c3c4b40a28195e3c7ee212aTest
رقم الانضمام: edsdoj.7c057a3b7c3c4b40a28195e3c7ee212a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:27306011
DOI:10.1007/s12672-022-00473-6