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1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity

التفاصيل البيبلوغرافية
العنوان: 1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity
المؤلفون: Jean Guillon, Solène Savrimoutou, Sandra Rubio, Stéphane Moreau, Noël Pinaud, Mathieu Marchivie, Vanessa Desplat
المصدر: Molbank, Vol 2020, Iss 1, p M1113 (2020)
بيانات النشر: MDPI AG, 2020.
سنة النشر: 2020
المجموعة: LCC:Inorganic chemistry
مصطلحات موضوعية: pyrrolo[1,2-a]quinoxaline derivative, leukemia, antiproliferative activity, Inorganic chemistry, QD146-197
الوصف: 1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one has been successfully synthesized via a multi-step pathway starting from 2-nitroaniline. Structure characterization of this original pyrrolo[1,2-a]quinoxaline derivative was achieved by FT-IR, 1H-NMR, 13C-NMR, X-Ray and HRMS spectral analysis. This title compound shows interesting cytotoxic potential against several human leukemia cell lines (K562, HL60, and U937 cells).
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-8599
العلاقة: https://www.mdpi.com/1422-8599/2020/1/M1113Test; https://doaj.org/toc/1422-8599Test
DOI: 10.3390/M1113
الوصول الحر: https://doaj.org/article/7af8c00ab5ba45e4a462029a296aad95Test
رقم الانضمام: edsdoj.7af8c00ab5ba45e4a462029a296aad95
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14228599
DOI:10.3390/M1113