دورية أكاديمية
Association between handgrip strength and bone mass parameters in HIV-infected children and adolescents. A cross-sectional study
| العنوان: | Association between handgrip strength and bone mass parameters in HIV-infected children and adolescents. A cross-sectional study |
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| المؤلفون: | Priscila Custódio Martins, Luiz Rodrigo Augustemak de Lima, Tiago Rodrigues de Lima, Edio Luiz Petroski, Diego Augusto Santos Silva |
| المصدر: | São Paulo Medical Journal, Vol 139, Iss 4, Pp 405-411 (2021) |
| بيانات النشر: | Associação Paulista de Medicina, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Body composition, Bone and bones, Child health, Adolescent health, Body fat, Children’s health, Teen health, Medicine |
| الوصف: | ABSTRACT BACKGROUND: Low bone mineral content (BMC) and bone mineral density (BMD) have been identified in human immunodeficiency virus (HIV)-infected children and adolescents. The direct adverse effects of HIV infection and combined antiretroviral therapy (ART) negatively contribute to bone metabolism. A direct relationship between muscle strength levels and BMD in HIV-infected adults and older adults has been described. However, it is unknown whether handgrip strength (HGS) is associated with bone mass in pediatric populations diagnosed with HIV. OBJECTIVE: To ascertain whether HGS levels are associated with BMC and BMD in HIV-infected children and adolescents. DESIGN AND SETTING: Cross-sectional study conducted in Florianãpolis, Brazil, in 2016. METHODS: The subjects were 65 children and adolescents (8-15 years) diagnosed with vertically-transmitted HIV. Subtotal and lumbar-spine BMC and BMD were obtained via dual-emission X-ray absorptiometry (DXA). HGS was measured using manual dynamometers. The covariates of sex, ART, CD4+ T lymphocytes and viral load were obtained through questionnaires and medical records. Sexual maturation was self-reported and physical activity was measured using accelerometers. Simple and multiple linear regression were used, with P < 0.05. RESULTS: HGS was directly associated with subtotal BMD (β = 0.002; R² = 0.670; P < 0.001), subtotal BMC (β = 0.090; R² = 0.734; P = 0.005) and lumbar-spine BMC (β = 1.004; R² = 0.656; P = 0.010) in the adjusted analyses. However, no significant association was found between HGS and lumbar-spine BMD (β = 0.001; R² = 0.464; P = 0.299). CONCLUSION: HGS was directly associated with BMD and BMC in HIV-infected children and adolescents. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1806-9460 1516-3180 |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000400405&tlng=enTest; https://doaj.org/toc/1806-9460Test |
| DOI: | 10.1590/1516-3180.2020.0539.r1.090321 |
| الوصول الحر: | https://doaj.org/article/7af70c35f375499a801b02db2e803f74Test |
| رقم الانضمام: | edsdoj.7af70c35f375499a801b02db2e803f74 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18069460 15163180 |
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| DOI: | 10.1590/1516-3180.2020.0539.r1.090321 |