دورية أكاديمية
Immunogenicity of high-dose trivalent inactivated influenza vaccine: a systematic review and meta-analysis
| العنوان: | Immunogenicity of high-dose trivalent inactivated influenza vaccine: a systematic review and meta-analysis |
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| المؤلفون: | Sandrine I. Samson, Phillip S. Leventhal, Camille Salamand, Ya Meng, Bruce T. Seet, Victoria Landolfi, David Greenberg, Rosalind Hollingsworth |
| المصدر: | Expert Review of Vaccines, Vol 18, Iss 3, Pp 295-308 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Internal medicine |
| مصطلحات موضوعية: | elderly adults, high-dose influenza vaccine, immunocompromised, immunogenicity, systematic review, Internal medicine, RC31-1245 |
| الوصف: | Introduction: High-dose trivalent, inactivated, split-virus influenza vaccine (IIV3-HD) has been available in the US since 2009 for adults aged ≥ 65 years. To better understand how IIV3-HD provides improved protection against influenza, we systematically reviewed clinical studies comparing immune responses to IIV3-HD and standard-dose trivalent vaccine (IIV3-SD). Areas covered: The primary objective was to determine the relative hemagglutination inhibition (HAI) antibody response of IIV3-HD vs. IIV3-SD in adults aged ≥ 65 years. Based on seven randomized studies including more than 18,500 adults aged ≥ 65 years, combined HAI geometric mean titer (GMT) ratios (95% confidence interval) approximately 1 month post-vaccination were 1.74 (1.65–1.83) for influenza A/H1N1, 1.84 (1.73–1.95) for influenza A/H3N2, and 1.47 (1.36–1.58) for influenza B. HAI GMT ratios in these studies were similar irrespective of sex, older age (≥ 75 years), frailty, and underlying conditions. Trends were similar for A/H3N2 neutralization and anti-neuraminidase antibody titers. In immunocompromised individuals, HAI GMT ratios were mostly > 1. Expert opinion: In agreement with its improved efficacy and effectiveness, IIV3-HD is consistently more immunogenic than IIV3-SD in adults aged ≥ 65 years. IIV3-HD also appears more immunogenic in immunocompromised individuals. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1476-0584 1744-8395 14760584 |
| العلاقة: | https://doaj.org/toc/1476-0584Test; https://doaj.org/toc/1744-8395Test |
| DOI: | 10.1080/14760584.2019.1575734 |
| الوصول الحر: | https://doaj.org/article/78a740013bef45de9ac94c5284ba147eTest |
| رقم الانضمام: | edsdoj.78a740013bef45de9ac94c5284ba147e |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 14760584 17448395 |
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| DOI: | 10.1080/14760584.2019.1575734 |