دورية أكاديمية
Clinical efficacy of tirofiban combined with a Solitaire stent in treating acute ischemic stroke
| العنوان: | Clinical efficacy of tirofiban combined with a Solitaire stent in treating acute ischemic stroke |
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| المؤلفون: | Yang Zhang, Qing-Qing Zhang, Cong Fu, Lei Wang, Guan-Qun Zhang, Pei-Wei Cao, Guo-Fang Chen, Xin-Min Fu |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 52, Iss 10 |
| بيانات النشر: | Associação Brasileira de Divulgação Científica. |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Acute ischemic stroke, Solitaire AB stent, Endovascular thrombectomy, Tirofiban, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | This study explores the safety and effect of acute cerebral infarction treatment by microcatheter injection of tirofiban combined with a Solitaire AB stent and/or stent implantation. Emergency cerebral angiograms showing the responsible vascular occlusion of 120 acute cerebral infarction patients who underwent emergency endovascular thrombectomy were included in the study. These patients were randomly divided into two groups using the random number table method: treatment group (n=60) that received thrombectomy (with cerebral artery stents) combined with intracerebral injection of tirofiban and control group (n=60) that only received thrombectomy (with cerebral artery stents alone). The baseline data, cerebral angiography before and after surgery, hospitalization, and follow-up results of patients in these two groups were compared. Furthermore, the incidence of major adverse cerebrovascular events of these two groups was compared (90-day modified Rankin scale, a score of 0–2 indicates a good prognosis). The difference between baseline clinical data and brain angiography between these two groups was not statistically significant. Patients in the treatment group had a higher prevalence of thrombolysis in cerebral infarction grade 2b/3 than patients in the control group (88.3% (53/60) vs 66.7% (40/60), P=0.036). Moreover, the National Institutes of Health Stroke Scale scores 7 days after surgery and the 90-day prognosis were all better for the patients who received tirofiban (P=0.048 and P=0.024). Mechanical thrombectomy with Solitaire AB stents in combination with the injection of tirofiban through a microcatheter appears to be safe and effective for the endovascular treatment of acute ischemic stroke. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1414-431X 1414-431x |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001000603&lng=en&tlng=enTest; https://doaj.org/toc/1414-431XTest |
| DOI: | 10.1590/1414-431x20198396 |
| الوصول الحر: | https://doaj.org/article/78955c9acaa34e6ab0df7147967e8424Test |
| رقم الانضمام: | edsdoj.78955c9acaa34e6ab0df7147967e8424 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 1414431X 1414431x |
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| DOI: | 10.1590/1414-431x20198396 |