دورية أكاديمية
Biliary Strictures and Cholangiocarcinoma – Untangling a Diagnostic Conundrum
| العنوان: | Biliary Strictures and Cholangiocarcinoma – Untangling a Diagnostic Conundrum |
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| المؤلفون: | Alexander Ney, Andres Garcia-Sampedro, George Goodchild, Pilar Acedo, Giuseppe Fusai, Stephen P. Pereira |
| المصدر: | Frontiers in Oncology, Vol 11 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | cholangiocarcinoma, primary sclerosing cholangitis (PSC), biliary strictures, ERCP (Endoscopic Retrograde Cholangiopancreatography), early detection, biomarkers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Cholangiocarcinoma is an uncommon and highly aggressive biliary tract malignancy with few manifestations until late disease stages. Diagnosis is currently achieved through a combination of clinical, biochemical, radiological and histological techniques. A number of reported cancer biomarkers have the potential to be incorporated into diagnostic pathways, but all lack sufficient sensitivity and specificity limiting their possible use in screening and early diagnosis. The limitations of standard serum markers such as CA19-9, CA125 and CEA have driven researchers to identify multiple novel biomarkers, yet their clinical translation has been slow with a general requirement for further validation in larger patient cohorts. We review recent advances in the diagnostic pathway for suspected CCA as well as emerging diagnostic biomarkers for early detection, with a particular focus on non-invasive approaches. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2234-943X 44139381 |
| العلاقة: | https://www.frontiersin.org/articles/10.3389/fonc.2021.699401/fullTest; https://doaj.org/toc/2234-943XTest |
| DOI: | 10.3389/fonc.2021.699401 |
| الوصول الحر: | https://doaj.org/article/77f838fe40cf44139381510d63ccff81Test |
| رقم الانضمام: | edsdoj.77f838fe40cf44139381510d63ccff81 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2234943X 44139381 |
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| DOI: | 10.3389/fonc.2021.699401 |