دورية أكاديمية
أعرض في EDS

Seroprevalence of Toxoplasma gondii and Borrelia burgdorferi infections in patients with multiple sclerosis in Poland

التفاصيل البيبلوغرافية
العنوان: Seroprevalence of Toxoplasma gondii and Borrelia burgdorferi infections in patients with multiple sclerosis in Poland
المؤلفون: Agnieszka Pawełczyk, Katarzyna Donskow-Łysoniewska, Ludmiła Szewczak, Magdalena Kierasińska, Maja Machcińska, Rafał Rola, Renata Welc-Falęciak
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Multiple sclerosis, Toxoplasmosis, Lyme disease, Lyme borreliosis, Toxoplasma, Borrelia, Medicine, Science
الوصف: Abstract Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system that affects mainly young people. It is believed that the autoimmune process observed in the pathogenesis of MS is influenced by a complex interaction between genetic and environmental factors, including infectious agents. The results of this study suggest the protective role of Toxoplasma gondii infections in MS. Interestingly, high Toxoplasma IgM seropositivity in MS patients receiving immunomodulatory drugs (IMDs) was identified. On the other hand, Borrelia infections seem to be positively associated with MS. Although the interpretation of our results is limited by the retrospective nature of the studies, the results strongly indicate that further experimental and clinical studies are needed to explain the role of infectious agents in the development and pathophysiological mechanisms of MS.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
العلاقة: https://doaj.org/toc/2045-2322Test
DOI: 10.1038/s41598-024-61714-y
الوصول الحر: https://doaj.org/article/75d3b2418d5c45da99042d61b9525718Test
رقم الانضمام: edsdoj.75d3b2418d5c45da99042d61b9525718
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-024-61714-y