دورية أكاديمية
Recovery of the first full-length genome sequence of a parapoxvirus directly from a clinical sample
| العنوان: | Recovery of the first full-length genome sequence of a parapoxvirus directly from a clinical sample |
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| المؤلفون: | Thomas Günther, Ludwig Haas, Malik Alawi, Peter Wohlsein, Jerzy Marks, Adam Grundhoff, Paul Becher, Nicole Fischer |
| المصدر: | Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
| بيانات النشر: | Nature Portfolio, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract We recovered the first full-length poxvirus genome, including the terminal hairpin region, directly from complex clinical material using a combination of second generation short read and third generation nanopore sequencing technologies. The complete viral genome sequence was directly recovered from a skin lesion of a grey seal thereby preventing sequence changes due to in vitro passaging of the virus. Subsequent analysis of the proteins encoded by this virus identified genes specific for skin adaptation and pathogenesis of parapoxviruses. These data warrant the classification of seal parapoxvirus, tentatively designated SePPV, as a new species within the genus Parapoxvirus. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | https://doaj.org/toc/2045-2322Test |
| DOI: | 10.1038/s41598-017-03997-y |
| الوصول الحر: | https://doaj.org/article/756dc6fd915c4b93802783d41f08e1caTest |
| رقم الانضمام: | edsdoj.756dc6fd915c4b93802783d41f08e1ca |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-017-03997-y |