دورية أكاديمية
Transverse aortic constriction induces gut barrier alterations, microbiota remodeling and systemic inflammation
| العنوان: | Transverse aortic constriction induces gut barrier alterations, microbiota remodeling and systemic inflammation |
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| المؤلفون: | Nicola Boccella, Roberta Paolillo, Lorena Coretti, Stefania D’Apice, Adriano Lama, Giuseppe Giugliano, Gabriele Giacomo Schiattarella, Mariella Cuomo, Ilaria d’Aquino, Gina Cavaliere, Orlando Paciello, Maria Pina Mollica, Giuseppina Mattace Raso, Giovanni Esposito, Francesca Lembo, Cinzia Perrino |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Accumulating evidence suggests that modifications of gut function and microbiota composition might play a pivotal role in the pathophysiology of several cardiovascular diseases, including heart failure (HF). In this study we systematically analysed gut microbiota composition, intestinal barrier integrity, intestinal and serum cytokines and serum endotoxin levels in C57BL/6 mice undergoing pressure overload by transverse aortic constriction (TAC) for 1 and 4 weeks. Compared to sham-operated animals, TAC induced prompt and strong weakening of intestinal barrier integrity, long-lasting decrease of colon anti-inflammatory cytokine levels, significant increases of serum levels of bacterial lipopolysaccharide and proinflammatory cytokines. TAC also exerted effects on microbiota composition, inducing significant differences in bacterial genera inside Actinobacteria, Firmicutes, Proteobacteria and TM7 phyla as shown by 16S rDNA sequencing of fecal samples from TAC or sham mice. These results suggest that gut modifications represent an important element to be considered in the development and progression of cardiac dysfunction in response to TAC and support this animal model as a valuable tool to establish the role and mechanisms of gut-heart crosstalk in HF. Evidence arising in this field might identify new treatment options targeting gut integrity and microbiota components to face adverse cardiac events. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | https://doaj.org/toc/2045-2322Test |
| DOI: | 10.1038/s41598-021-86651-y |
| الوصول الحر: | https://doaj.org/article/c74fa22f500346549147bf13cc6d2327Test |
| رقم الانضمام: | edsdoj.74fa22f500346549147bf13cc6d2327 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-021-86651-y |