دورية أكاديمية
Association of SRXN1 receptor gene polymorphism with susceptibility to periodontitis
| العنوان: | Association of SRXN1 receptor gene polymorphism with susceptibility to periodontitis |
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| المؤلفون: | Karthikeyan Murthykumar, Sheeja Varghese, Vijayashree Priyadharsini Jayaseelan |
| المصدر: | Contemporary Clinical Dentistry, Vol 13, Iss 4, Pp 363-368 (2022) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Dentistry |
| مصطلحات موضوعية: | alleles, periodontitis, polymorphism, srxn1 receptor, Dentistry, RK1-715 |
| الوصف: | Background: Emerging evidence suggests that oxidative stress forms a key component in the etiopathogenesis of periodontitis. Literature evidence have shown potential antioxidants responsible for combating the pro-oxidants which stress the periodontium, but the peroxiredoxin-sulfiredoxin system is explored very minimally in periodontal disease. Thus, the present study was aimed to evaluate the genetic association of SRXN1 receptor gene polymorphism (rs6053666). Materials and Methods: A total of 100 subjects were recruited for this study, which included 50 Periodontitis patients (Stage II and above based on the criteria of American Association of Periodontology-2018) and 50 periodontally healthy or mild gingivitis. Genomic DNA was extracted from the whole blood collected from the subjects. DNA was amplified using specific primers flanking the BtgI region of the SRXN1 receptor gene. The amplicon was further subjected to genotyping using restriction fragment length using BtgI enzyme. The genotype obtained based on the restriction fragment length polymorphism pattern was recorded and used for statistical analysis. The distribution of genotypes and allele frequencies in the periodontitis and control groups were compared using the Chi-square test. The risk associated with individual alleles or genotypes was calculated as the odds ratio with 95% confidence intervals. Statistical significance in all tests was determined at P < 0.05. Results: The genotype frequency and distributions of SRXN1 receptor BtgI polymorphism did not differ significantly at ꭕ2df (P = 0.557). Our study results showed that homozygous and heterozygous mutant genotypes had no significant difference (CC vs. CT + TT) between the periodontitis patients and control group with a P = 0.4266. The detected frequency of CT (38% vs. 34%) and TT (42% vs. 52%) genotype showed no significant difference between control and test group. There was no significant difference in C allele (39% vs. 31%) and T allele (61% vs. 69%) between the test and control group. Conclusion: The present study denotes that SRXN1 receptor gene polymorphism is not associated with periodontitis in the study group analyzed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0976-237X 0976-2361 |
| العلاقة: | http://www.contempclindent.org/article.asp?issn=0976-237X;year=2022;volume=13;issue=4;spage=363;epage=368;aulast=MurthykumarTest; https://doaj.org/toc/0976-237XTest; https://doaj.org/toc/0976-2361Test |
| DOI: | 10.4103/ccd.ccd_309_21 |
| الوصول الحر: | https://doaj.org/article/a6faa745178f40e8b435eeb4b25759fdTest |
| رقم الانضمام: | edsdoj.6faa745178f40e8b435eeb4b25759fd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 0976237X 09762361 |
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| DOI: | 10.4103/ccd.ccd_309_21 |