دورية أكاديمية
Changes in the expression of molecular markers of peripheral blood lymphocyte activation in patients with small (T1) choroidal melanoma after transpupillary thermotherapy
| العنوان: | Changes in the expression of molecular markers of peripheral blood lymphocyte activation in patients with small (T1) choroidal melanoma after transpupillary thermotherapy |
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| المؤلفون: | I.V. Tsukanova, S.I. Poliakova, L.M. Velichko, O.V. Bogdanova |
| المصدر: | Journal of Ophthalmology, Iss 5, Pp 27-29 (2019) |
| بيانات النشر: | Ukrainian Society of Ophthalmologists, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Internal medicine |
| مصطلحات موضوعية: | choroidal melanoma, transpupillary thermotherapy, molecular markers of peripheral blood lymphocyte activation, Internal medicine, RC31-1245 |
| الوصف: | Background: Expression of some functional molecules on peripheral blood lymphocytes is critically important for the development of adequate antitumor response. Purpose: To investigate changes in the expression of molecular markers of peripheral blood lymphocyte activation in patients with small (T1) choroidal melanoma (CM; measuring ? 3 mm in protrusion into the vitreous and ? 12 mm in basal dimension) after transpupillary thermotherapy (TTT) delivered using our methodology. Materials and Methods: We investigated the expression of molecular markers (СD7+, CD25+, CD38+, CD45+, CD54+, CD95+, CD150+) of peripheral blood lymphocyte activation using the routine methodology in 16 patients (12 women (75%) and 4 men (25%); mean age, 55.4 years (11.2 years)) with small (T1) CM at baseline and after a course of TTT delivered using our methodology. Statistical analyses were conducted using Statistica 10 (StatSoft, Tulsa, OK, USA) software. Results: Four-day activity of all examined peripheral blood lymphocyte subpopulations in patients was observed in response to the curative effect of 810-nm diode laser TTT on CM. However, statistically significant increases were found only for the expression of the costimulatory molecule inducing cytokine secretion (CD7+) and proaptotic lymphocyte activity due to an increased share of CD95+-phenotype cells. Conclusion: The expression of molecular markers of peripheral blood lymphocyte activation, especially the expression of the costimulatory molecule inducing cytokine secretion (CD7+) and proaptotic lymphocyte activity due to an increased share of CD95+-phenotype cells, increases within the course of TTT for the small (T1) CM. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Ukrainian |
| تدمد: | 2412-8740 |
| العلاقة: | https://www.ozhurnal.com/en/archive/2019/5/5-fulltextTest; https://doaj.org/toc/2412-8740Test |
| DOI: | 10.31288/oftalmolzh201952729 |
| الوصول الحر: | https://doaj.org/article/6ae249a023bf4a18bfc9150fa9e53e4eTest |
| رقم الانضمام: | edsdoj.6ae249a023bf4a18bfc9150fa9e53e4e |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 24128740 |
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| DOI: | 10.31288/oftalmolzh201952729 |