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Untargeted Lipidomics of Erythrocytes under Simulated Microgravity Conditions

التفاصيل البيبلوغرافية
العنوان: Untargeted Lipidomics of Erythrocytes under Simulated Microgravity Conditions
المؤلفون: Cristina Manis, Antonio Murgia, Alessia Manca, Antonella Pantaleo, Giacomo Cao, Pierluigi Caboni
المصدر: International Journal of Molecular Sciences, Vol 24, Iss 5, p 4379 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: lipidomics, mass spectrometry, microgravity condition, erythrocytes, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Lipidomics and metabolomics are nowadays widely used to provide promising insights into the pathophysiology of cellular stress disorders. Our study expands, with the use of a hyphenated ion mobility mass spectrometric platform, the understanding of the cellular processes and stress due to microgravity. By lipid profiling of human erythrocytes, we annotated complex lipids such as oxidized phosphocholines, phosphocholines bearing arachidonic in their moiety, as well as sphingomyelins and hexosyl ceramides associated with microgravity conditions. Overall, our findings give an insight into the molecular alterations and identify erythrocyte lipidomics signatures associated with microgravity conditions. If the present results are confirmed in future studies, they may help to develop suitable treatments for astronauts after return to Earth.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
العلاقة: https://www.mdpi.com/1422-0067/24/5/4379Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test
DOI: 10.3390/ijms24054379
الوصول الحر: https://doaj.org/article/6a686062109242b0a98f56ff6726fcc7Test
رقم الانضمام: edsdoj.6a686062109242b0a98f56ff6726fcc7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms24054379