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The central role of pathology labs in breast cancer precision oncology: a call for action

التفاصيل البيبلوغرافية
العنوان: The central role of pathology labs in breast cancer precision oncology: a call for action
المؤلفون: Giancarlo Pruneri, Daniele Lorenzini, Mauro G. Mastropasqua, Giuseppe Perrone, Antonio Rizzo, Donatella Santini, Chiara C. Volpi, Saverio Cinieri, Alberto Zambelli, Anna Sapino, Isabella Castellano
المصدر: npj Breast Cancer, Vol 9, Iss 1, Pp 1-4 (2023)
بيانات النشر: Nature Portfolio, 2023.
سنة النشر: 2023
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Multigenic tests represent an essential tool for the selection of adjuvant therapy in estrogen-positive/HER2-negative (ER + /HER2-) early breast cancer (BC). The workflow of these tests, either if they are externalized or carried out in-house, generates a workload for the pathology laboratories, that is often underestimated and may affect timely therapy initiation. Here, we describe the evolving role of pathology laboratories in using multigenic tests and, more in general, in providing adequate tissue for molecular analyses. Moreover, we propose a “reflex testing” model, in which pathologists, based on pre-specified and shared criteria, are expected to action multigene testing independently of multidisciplinary team discussion in ER + /HER2- BC patients, in order to optimize turnaround time and proper therapy intervention.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2374-4677
42729238
العلاقة: https://doaj.org/toc/2374-4677Test
DOI: 10.1038/s41523-023-00506-5
الوصول الحر: https://doaj.org/article/69dd406149ad42729238c4c9f88b56fdTest
رقم الانضمام: edsdoj.69dd406149ad42729238c4c9f88b56fd
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23744677
42729238
DOI:10.1038/s41523-023-00506-5