دورية أكاديمية
Cardiovascular effects of linalyl acetate in acute nicotine exposure
| العنوان: | Cardiovascular effects of linalyl acetate in acute nicotine exposure |
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| المؤلفون: | Ju Ri Kim, Purum Kang, Hui Su Lee, Ka Young Kim, Geun Hee Seol |
| المصدر: | Environmental Health and Preventive Medicine, Vol 22, Iss 1, Pp 1-7 (2017) |
| بيانات النشر: | Komiyama Printing Co. Ltd, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Linalyl acetate, Acute nicotine, Adolescent, Cardiovascular changes, Public aspects of medicine, RA1-1270 |
| الوصف: | Abstract Backgroud Smoking is a risk factor for cardiovascular diseases as well as pulmonary dysfunction. In particular, adolescent smoking has been reported to have a higher latent risk for cardiovascular disease. Despite the risk to and vulnerability of adolescents to smoking, the mechanisms underlying the effects of acute nicotine exposure on adolescents remain unknown. This study therefore evaluated the mechanism underlying the effects of linalyl acetate on cardiovascular changes in adolescent rats with acute nicotine exposure. Methods Parameters analyzed included heart rate (HR), systolic blood pressure, lactate dehydrogenase (LDH) activity, vascular contractility, and nitric oxide levels. Results Compared with nicotine alone, those treated with nicotine plus 10 mg/kg (p = 0.036) and 100 mg/kg (p = 0.023) linalyl acetate showed significant reductions in HR. Moreover, the addition of 1 mg/kg (p = 0.011), 10 mg/kg (p = 0.010), and 100 mg/kg (p = 0.011) linalyl acetate to nicotine resulted in significantly lower LDH activity. Nicotine also showed a slight relaxation effect, followed by a sustained recontraction phase, whereas nicotine plus linalyl acetate or nifedipine showed a constant relaxation effect on contraction of mouse aorta (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1342-078X 1347-4715 |
| العلاقة: | http://link.springer.com/article/10.1186/s12199-017-0651-6Test; https://doaj.org/toc/1342-078XTest; https://doaj.org/toc/1347-4715Test |
| DOI: | 10.1186/s12199-017-0651-6 |
| الوصول الحر: | https://doaj.org/article/6728da792aed43dbb6f980dd95d48a72Test |
| رقم الانضمام: | edsdoj.6728da792aed43dbb6f980dd95d48a72 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1342078X 13474715 |
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| DOI: | 10.1186/s12199-017-0651-6 |