دورية أكاديمية
Vitamin D and the microbiota connection: understanding its potential to improve COPD outcomes
| العنوان: | Vitamin D and the microbiota connection: understanding its potential to improve COPD outcomes |
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| المؤلفون: | Asmaa Ali, Liang Wu, Sameh Samir Ali |
| المصدر: | The Egyptian Journal of Bronchology, Vol 18, Iss 1, Pp 1-17 (2024) |
| بيانات النشر: | SpringerOpen, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the respiratory system LCC:Medical emergencies. Critical care. Intensive care. First aid |
| مصطلحات موضوعية: | Vitamin D, Respiratory mucosa, COPD exacerbation, Microbiota, Preventive treatment, Diseases of the respiratory system, RC705-779, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| الوصف: | Abstract The mucosa of the respiratory system is an essential site for local vitamin D synthesis, degradation, and signaling. It modulates the inflammatory and immune response by saving the integrity of the mucosal barrier and killing the invading pathogen through the induction of antimicrobial peptides. The proper functioning of the immune system within the respiratory system is influenced by the complex interactions of numerous immune pathways, including the gut-lung axis. Recent research has indicated that the gut microbiota is vital in developing and progressing chronic inflammatory chest conditions, such as asthma and chronic obstructive pulmonary disease (COPD). Furthermore, the immune-modulating function of vitamin D operates through the gut mucosa; hence, the vitamin D receptor is expressed to regulate the antimicrobial peptide. The potential protective role of vitamin D and its correlation with COPD has garnered significant interest. It is currently under exploration as a possible adjuvant therapy to aid in managing frequent exacerbation of COPD. In this review, we explored the connection between vitamin D and the immune system, as well as its relationship with microbiota. We also summarized some novel mechanisms of action of vitamin D supplementation that can impact disease exacerbation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2314-8551 |
| العلاقة: | https://doaj.org/toc/2314-8551Test |
| DOI: | 10.1186/s43168-024-00271-4 |
| الوصول الحر: | https://doaj.org/article/66c997af4f084109b96d80efd89f74c0Test |
| رقم الانضمام: | edsdoj.66c997af4f084109b96d80efd89f74c0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23148551 |
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| DOI: | 10.1186/s43168-024-00271-4 |