دورية أكاديمية
Impact of daily plan adaptation on accumulated doses in ultra-hypofractionated magnetic resonance-guided radiation therapy of prostate cancer
| العنوان: | Impact of daily plan adaptation on accumulated doses in ultra-hypofractionated magnetic resonance-guided radiation therapy of prostate cancer |
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| المؤلفون: | Yuqing Xiong, Moritz Rabe, Carolin Rippke, Maria Kawula, Lukas Nierer, Sebastian Klüter, Claus Belka, Maximilian Niyazi, Juliane Hörner-Rieber, Stefanie Corradini, Guillaume Landry, Christopher Kurz |
| المصدر: | Physics and Imaging in Radiation Oncology, Vol 29, Iss , Pp 100562- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | MRgRT, Dose accumulation, Prostate, Online plan adaptation, Ultra-hypofractionation, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background and purpose: Ultra-hypofractionated online adaptive magnetic resonance-guided radiotherapy (MRgRT) is promising for prostate cancer. However, the impact of online adaptation on target coverage and organ-at-risk (OAR) sparing at the level of accumulated dose has not yet been reported. Using deformable image registration (DIR)-based accumulation, we compared the delivered adapted dose with the simulated non-adapted dose. Materials and methods: Twenty-three prostate cancer patients treated at two clinics with 0.35 T magnetic resonance-guided linear accelerator (MR-linac) following the same treatment protocol (5 × 7.5 Gy with urethral sparing and daily adaptation) were included. The fraction MR images were deformably registered to the planning MR image. Both non-adapted and adapted fraction doses were accumulated with the corresponding vector fields. Two DIR approaches were implemented. PTV* (planning target volume minus urethra+2mm) D95%, CTV* (clinical target volume minus urethra) D98%, and OARs (urethra+2mm, bladder, and rectum) D0.2cc, were evaluated. Statistical significance was inferred from a two-tailed Wilcoxon signed-rank test (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-6316 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2405631624000320Test; https://doaj.org/toc/2405-6316Test |
| DOI: | 10.1016/j.phro.2024.100562 |
| الوصول الحر: | https://doaj.org/article/6557ad36836c4e799c07819f880ab6dcTest |
| رقم الانضمام: | edsdoj.6557ad36836c4e799c07819f880ab6dc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24056316 |
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| DOI: | 10.1016/j.phro.2024.100562 |